Evidence map›Paper›PMID 27476121›Full record

ReviewThe Urologic clinics of North America2016

Review of Prostate Anatomy and Embryology and the Etiology of Benign Prostatic Hyperplasia.

LaTayia Aaron, Omar E Franco, Simon W Hayward

Abstract readReview
In one paragraph

Review in The Urologic clinics of North America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 2 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 193 citations in OpenAlex.

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  16. Ectonucleotidases and purinergic receptors in mouse prostate gland.American journal of clinical and experimental urology · 2025
    Article
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

LaTayia AaronDepartment of Biochemistry and Cancer Biology, Meharry Medical College, 1005 DR DB Todd JR Blvd, Nashville, TN 37208, USA; Department of Surgery, NorthShore University HealthSystem Research Institute, 1001 University Place, Evanston, IL 60201, USA.
Omar E FrancoDepartment of Surgery, NorthShore University HealthSystem Research Institute, 1001 University Place, Evanston, IL 60201, USA.
Simon W HaywardDepartment of Biochemistry and Cancer Biology, Meharry Medical College, 1005 DR DB Todd JR Blvd, Nashville, TN 37208, USA; Department of Surgery, NorthShore University HealthSystem Research Institute, 1001 University Place, Evanston, IL 60201, USA. Electronic address: shayward@northshore.org.
Meharry Medical College · USNorthShore University HealthSystem · US

Funding

THE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0M
Meharry RCMI Program in Women's Health ResearchG12MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI HILDRETH, JAMES E · 2012 to 2016
$7.8M
AP-1 Factors in the Pathogenesis and Progression of Benign Prostatic HyperplasiaR01DK103483 · NIDDK · VANDERBILT UNIVERSITY · PI HAYWARD, SIMON W · 2014 to 2017
$1.3M
NIDDK NIH HHS R01 DK103483NIGMS NIH HHS R25 GM059994NIMHD NIH HHS G12 MD007586
6 · The paper itself

Abstract

Prostate development follows a common pattern between species and depends on the actions of androgens to induce and support ductal branching morphogenesis of buds emerging from the urogenital sinus. The human prostate has a compact zonal anatomy immediately surrounding the urethra and below the urinary bladder. Rodents have a lobular prostate with lobes radiating away from the urethra. The human prostate is the site of benign hyperplasia, prostate cancer, and prostatitis. The rodent prostate has little naturally occurring disease. Rodents can be used to model aspects of human benign hyperplasia, but care should be taken in data interpretation and extrapolation to the human condition.

Indexed as

Diagnostic Techniques, UrologicalProstatic HyperplasiaAnimalsHumansMaleProstateBPHLUTSProstate anatomyProstate embryology

Identifiers

PMID27476121
PMCPMC4968575
OpenAlexW2476720412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.