Evidence map›Paper›PMID 27476067›Full record

ReviewCurrent treatment options in neurology2016

Treatment of Sleep Disorders in Dementia.

Sharon Ooms, Yo-El Ju

3 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Current treatment options in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03066518 phase4completednot on this map

A Randomized Placebo-controlled Trial Evaluating the Effect of Melatonin on Sleep Quality in Patients With Dementia

TypeinterventionalSponsorHospital Universitario Dr. Jose E. GonzalezRan2016 to 2017Enrolled40ConditionsSleep Disorders, DementiaArmsMelatonin 5 mg, Placebo
NCT06857136 completednot on this mapstarted 2021, after this paper: background citation

The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH

TypeobservationalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2021 to 2024Enrolled29ConditionsHydrocephalus, Normal Pressure Hydrocephalus
NCT07768033 nacompletednot on this mapstarted 2026, after this paper: background citation

The effect of chair-assisted yoga practice on sleep quality and pain levels in elderly individuals living in nursing homes

TypeinterventionalSponsorRüveyda BerkRan2026 to 2026Enrolled36ConditionsSleep Quality, PainArmsChair-Supported Yoga
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. The DREAMS START intervention for sleep in dementia: Long-term follow-up of a randomized controlled trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Trial
  3. Observational
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Sleep efficiency in community-dwelling persons living with dementia: exploratory analysis using machine learning.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Observational
  10. Article
  11. Article
  12. Article
  13. Sleep disturbances as risk factors for neurodegeneration later in life.medRxiv : the preprint server for health sciences · 2023
    Article
  14. Review
  15. Article
  16. The Effect of Agomelatine in Behavioral and Psychological Symptoms of Dementia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Sharon OomsDepartment of Geriatric Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Yo-El JuDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, Saint Louis, MO, 63110, USA. juy@neuro.wustl.edu.
Radboud University Medical Center · NLWashington University in St. Louis · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8M
TARGETING SLOW WAVE SLEEP TO CONTROL NEURONAL ACTIVITY AND AMYLOID-BETA DYNAMICSK23NS089922 · NINDS · WASHINGTON UNIVERSITY · PI JU, YO-EL S · 2015 to 2019
$889k
NCATS NIH HHS KL2 TR000450NCATS NIH HHS UL1 TR000448NINDS NIH HHS K23 NS089922
6 · The paper itself

Abstract

opinion statementSleep and circadian disorders occur frequently in all types of dementia. Due to the multifactorial nature of sleep problems in dementia, we propose a structured approach to the evaluation and treatment of these patients. Primary sleep disorders such as obstructive sleep apnea should be treated first. Comorbid conditions and medications that impact sleep should be optimally managed to minimize negative effects on sleep. Patients and caregivers should maintain good sleep hygiene, and social and physical activity should be encouraged during the daytime. Given the generally benign nature of bright light therapy and melatonin, these treatments should be tried first. Pharmacological treatments should be added cautiously, due to the risk of cognitive side effects, sedation, and falls in the demented and older population. Regardless of treatment modality, it is essential to follow patients with dementia and sleep disorders closely, with serial monitoring of individual response to treatment.

Indexed as

Alzheimer’s diseaseCircadianDementiaDementia with Lewy bodiesFrontotemporal dementiaInsomniaLewy body diseaseParkinson’s disease with dementiaREM sleep behavior disorderSleepVascular dementia

Identifiers

PMID27476067
PMCPMC5363179
OpenAlexW2493022745

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.