GuidelineThe Journal of urology2016
Design and Methodological Considerations of the Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida.
Guideline in The Journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03959163 (The Validity of the Quick Renal MRI in Pediatric Kidney Disease), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Validity of the Quick Renal MRI in Pediatric Kidney Disease
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Electrostimulation in Children With Neurogenic Bladder due to Spina Bifida: Systematic Review and Meta-Analysis.Birth defects research · 2025Pooled it
- Anorectal manometry and urodynamics in children with spina bifida: can we predict the colonic dysmotility from bladder dysfunction?BMC urology · 2024Trial
- Kidney Morbidity in Pediatric Patients With Spina Bifida.JAMA network open · 2026Article
- Diagnostic Accuracy of Urine Microbial Diversity and Urine Neutrophil Gelatinase-Associated Lipocalin for the Diagnosis of Urinary Tract Infections in Children with Spina Bifida.The Journal of pediatrics · 2026Article
- Transitional urology: a comprehensive review of the transitional care process.Nature reviews. Urology · 2026Review
- Urodynamics assessment in patients with multiple sclerosis.BJUI compass · 2026Article
- Fetoscopic three-port, three-layer open spina bifida repair.Neurosurgical focus: Video · 2026Article
- Diffusion-weighted imaging of the spinal cord in children after prenatal myelomeningocele repair.Pediatric radiology · 2026Article
- Quality of life in children with myelomeningocele undergoing intrauterine repair and postnatal surgery.The journal of spinal cord medicine · 2026Article
- Diagnostic evaluation and treatment of UTIs in children with neurogenic bladder.Journal of pediatric urology · 2026Article
- Dynamic ultrasound evaluation of morphological and functional urinary tract characteristics in newborns and young infants with myelomeningocele.Pediatric radiology · 2026Article
- Role of urodynamics in predicting fecal incontinence in spina bifida and spinal cord injury patients.Pediatric surgery international · 2025Observational
- Diagnostic Test Characteristics of Ultrasound-Based Hydronephrosis for Chronic Kidney Disease in Children and Adolescents With Myelomeningocele: Results From the UMPIRE and National Spina Bifida Patient Registry Cohort Studies.The Journal of urology · 2025Article
- Multidisciplinary management of people with spina bifida across the lifespan.Pediatric nephrology (Berlin, Germany) · 2024Review
- OnabotulinumtoxinA is now an important tool for managing pediatric neurogenic lower urinary tract dysfunction.Frontiers in pediatrics · 2024Review
- 2023 Canadian Urological Association/Pediatric Urologists of Canada guideline: Pediatric patients with neurogenic lower urinary tract dysfunction Full-text version.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023Article
- Association between age of starting clean intermittent catheterization and current urinary continence in individuals with myelomeningocele.Journal of pediatric urology · 2022Article
- Variation in Definitions of Kidney Abnormality in Patients with Spina Bifida: A Systematic Scoping Review.The Journal of urology · 2022Article
- The impact of constant antibiotic prophylaxis in children affected by spinal dysraphism performing clean intermittent catheterization: a 2-year monocentric retrospective analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Prevention and awareness of birth defects across the lifespan using examples from congenital heart defects and spina bifida.Birth defects research · 2022Article
Corrections and comments
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Authors and funding
20 authors at 16 institutions in 1 country.
Funding
Abstract
purposeCare of children with spina bifida has significantly advanced in the last half century, resulting in gains in longevity and quality of life for affected children and caregivers. Bladder dysfunction is the norm in patients with spina bifida and may result in infection, renal scarring and chronic kidney disease. However, the optimal urological management for spina bifida related bladder dysfunction is unknown. MATERIALS AND
methodsIn 2012 the Centers for Disease Control and Prevention convened a working group composed of pediatric urologists, nephrologists, epidemiologists, methodologists, community advocates and Centers for Disease Control and Prevention personnel to develop a protocol to optimize urological care of children with spina bifida from the newborn period through age 5 years.
resultsAn iterative quality improvement protocol was selected. In this model participating institutions agree to prospectively treat all newborns with spina bifida using a single consensus based protocol. During the 5-year study period outcomes will be routinely assessed and the protocol adjusted as needed to optimize patient and process outcomes. Primary study outcomes include urinary tract infections, renal scarring, renal function and bladder characteristics. The protocol specifies the timing and use of testing (eg ultrasonography, urodynamics) and interventions (eg intermittent catheterization, prophylactic antibiotics, antimuscarinic medications). Starting in 2014 the Centers for Disease Control and Prevention began funding 9 study sites to implement and evaluate the protocol.
conclusionsThe Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida began accruing patients in 2015. Assessment in the first 5 years will focus on urinary tract infections, renal function, renal scarring and clinical process improvements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.