ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016
Chronic oral mucositis after radiotherapy to the head and neck: a new insight.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04308161 (The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Prevalence and characteristics of persistent pain among head and neck cancer survivors: a systematic review and meta-analysis.Pain medicine (Malden, Mass.) · 2025Pooled it
- Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022.Frontiers in oncology · 2022Pooled it
- MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy.Cancer · 2020Guideline
- From clinic to couch: a pilot study of home-use photobiomodulation for radiation-induced oral mucositis and dermatitis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Regimen-Related Oral Mucosal Injury: Pathobiology, Clinical Consequences and Rationale for Intervention Across Cancer Treatment Modalities.Current oncology reports · 2026Review
- Potentiality of Curcumin Against Radio-Chemotherapy Induced Oral Mucositis: A Review.Indian journal of surgical oncology · 2025Review
- The Influence of the Microbiome on the Complications of Radiotherapy and Its Effectiveness in Patients with Laryngeal Cancer.Cancers · 2024Article
- Oral health related quality of life in head and neck cancer survivors within the first year following treatment: a cross-sectional study in Karachi, Pakistan.Scientific reports · 2024Article
- Attempts to Understand Oral Mucositis in Head and Neck Cancer Patients through Omics Studies: A Narrative Review.International journal of molecular sciences · 2023Review
- Oral Complications from Oropharyngeal Cancer Therapy.Cancers · 2023Review
- Gold nanomaterials for oral cancer diagnosis and therapy: Advances, challenges, and prospects.Materials today. Bio · 2022Article
- Dental management of a patient with head and neck cancer: a case report.British dental journal · 2019Article
- Treatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study.Lasers in medical science · 2018Article
- Management of radiation-induced mucosal necrosis with photobiomodulation therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma.PloS one · 2018Article
- Oral complications at 6 months after radiation therapy for head and neck cancer.Oral diseases · 2017Article
- Effect of Tempol on the prevention of irradiation-induced mucositis in miniature pigs.Oral diseases · 2017Article
- Effectiveness of an Interdisciplinary Medical Hospital Admission Center: The Role of the Dental Section in the Interdisciplinary System for Perioperative Management of Patients Awaiting Surgery.Journal of medical systems · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOral mucositis is a major complication of anticancer therapy yet the literature focuses on immediate (acute) mucosal changes and hardly describes the chronic form. We aim to report the clinical manifestations of chronic mucositis.
methodsA retrospective chart review of oral mucositis referrals was performed. Inclusion/exclusion criteria defined the patients that were considered to have chronic mucositis.
resultsFour female patients treated for tongue/lower lip squamous cell carcinoma were included. Extensive painful oral mucositis lesions developed in all patients during the course of radiotherapy, with ulcers remaining for 5-24 months after completion of therapy. We describe two presentations, namely the persistent form (long-lasting ulcers continuing from acute ulcers) and the recurrent form (new discrete ulcers appearing on atrophic mucosa following the completion of radiotherapy).
conclusionsThe long-term oral complications of radiotherapy to the head and neck may include chronic atrophic, erythematous, and/or ulcerated lesions. A diagnosis of chronic oral mucositis should be considered when the lesions are observed at least 3 months after radiotherapy, and other possible etiologies have been excluded. The influence of age and comorbidities (primarily diabetes mellitus) on chronic mucositis, the significance to patient's quality of life, and the management of chronic mucositis are important subjects for future research.
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