SynthesisMedicina oral, patologia oral y cirugia bucal2016
Current methods of sedation in dental patients - a systematic review of the literature.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.BMJ open · 2021Pooled it
- Effect of Dexmedetomidine with or without Midazolam during procedural dental sedation in children: a randomized controlled clinical trial.BMC oral health · 2024Trial
- Influence of Temperament on the Acceptance of Two Conscious Sedation Techniques in Toddlers Undergoing Dental Treatment: A Randomised Cross Over Trial.Pain research & management · 2023Trial
- Trial
- Midazolam versus midazolam-promethazine combination for oral sedation in third molar surgery: A randomized split-mouth trial.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Procedural sedation in dentistry: a scoping review and proposal for an ad hoc informed consent.BMC medical ethics · 2026Article
- Identification of quality and safety concerns in AI chatbot responses to procedural sedation: a comparative evaluation of ChatGPT, Gemini, and Copilot.Frontiers in health services · 2026Article
- Safety and Satisfaction Analysis of Intravenous and Inhalational Conscious Sedation in a Geriatric Population Undergoing Oral Surgery.Healthcare (Basel, Switzerland) · 2025Article
- Evaluation of the Efficacy of Buccal Midazolam in Comparison With Intranasal Midazolam Sedation in Uncooperative Children During Dental Treatment.International journal of dentistry · 2025Article
- γ-Aminobutyric acid type A receptor β1 subunit gene polymorphisms are associated with the sedative and amnesic effects of midazolam.Molecular brain · 2024Article
- Review
- Ketamine-propofol (ketofol) in procedural sedation: a narrative review.Journal of dental anesthesia and pain medicine · 2023Review
- Establishment of an intravenous conscious sedation service at a University Dental Clinic in Tanzania.Journal of dental anesthesia and pain medicine · 2023Article
- Physiological reaction of anxious patients taking sedative medications before and after periodontal surgery.Journal of dental sciences · 2023Article
- Parental preferences for the procedural sedation of children in dentistry: a discrete choice experiment.Frontiers in pediatrics · 2023Article
- Conscious sedation in dentistry: knowledge and practice among dental professionals in Tanzania.Journal of dental anesthesia and pain medicine · 2021Article
- Dispensing patterns of medicines prescribed by Australian dentists from 2006 to 2018 - a pharmacoepidemiological study.International dental journal · 2020Article
- Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: protocol for a systematic review.BMJ open · 2018Article
- Trends for in-office usage of pharmacological sedation agents in India: A narrative review.Journal of anaesthesiology, clinical pharmacologyReview
- Indian Society of Periodontology Good Clinical Practice Recommendations for dental pain management and use of analgesics.Journal of Indian Society of PeriodontologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe main objective of this systematic literature review is to identify the safest and most effective sedative drugs so as to ensure successful sedation with as few complications as possible. STUDY
designA systematic literature review of the PubMed MEDLINE database was carried out using the key words "conscious sedation," "drugs," and "dentistry." A total of 1,827 scientific articles were found, and these were narrowed down to 473 articles after applying inclusion and exclusion criteria. These 473 studies were then individually assessed for their suitability for inclusion in this literature review.
resultsA total of 21 studies were selected due to their rigorous study design and conduciveness to further, more exhaustive analysis. The selected studies included a total of 1,0003 patients classified as ASA I or II. Midazolam was the drug most frequently used for successful sedation in dental surgical procedures. Ketamine also proved very useful when administered intranasally, although some side effects were observed when delivered via other routes of administration. Both propofol and nitrous oxide (N2O) are also effective sedative drugs.
conclusionsMidazolam is the drug most commonly used to induce moderate sedation in dental surgical procedures, and it is also very safe. Other sedative drugs like ketamine, dexmedetomidine and propofol have also been proven safe and effective; however, further comparative clinical studies are needed to better demonstrate which of these are the safest and most effective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.