Evidence map›Paper›PMID 27475412›Full record

ArticleFertility and sterility2016

Immune-inflammation gene signatures in endometriosis patients.

Soo Hyun Ahn, Kasra Khalaj, Steven L Young, Bruce A Lessey, Madhuri Koti, Chandrakant Tayade

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 5 pooled it
18.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 5 syntheses or guidelines pooled it, 188 citations in OpenAlex.

  1. Pooled it
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  6. Article
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  14. The Role of the Microbiome in Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Endometriosis: An Immunologist's Perspective.International journal of molecular sciences · 2025
    Review
  20. Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Soo Hyun AhnDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Kasra KhalajDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Steven L YoungDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
Bruce A LesseyDepartment of Obstetrics and Gynecology, Greenville Health Systems, Greenville, South Carolina.
Madhuri KotiDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Chandrakant TayadeDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. Electronic address: tayadec@queensu.ca.
Queen's University · CAPrisma Health · USUniversity of North Carolina at Chapel Hill · US

Funding

Progesterone Action in the Endometrium of Women with EndometriosisR01HD067721 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YOUNG, STEVEN L · 2011 to 2015
$3.1M
NICHD NIH HHS R01 HD067721
6 · The paper itself

Abstract

objectiveTo determine if the molecular profiles of endometriotic lesions contain informative measures of inflammation and immune dysfunction that may contribute to better understanding of the interplay between immune dysfunction and inflammation and their contribution to endometriosis pathogenesis.

designImmune and inflammation transcriptomic analysis with the use of the Nanostring nCounter GX Human Immunology V2 platform (579 human immune and inflammation-related genes and 15 housekeeping genes).

settingAcademic university and teaching hospital. INTERVENTION(S): None. PATIENT(S): Stage III-IV endometriosis patients with infertility (n = 8) and fertile disease-free control women undergoing tubal ligation (n = 8). Menstrual stage was matched to secretory phase in all participants. MAIN OUTCOME MEASURE(S): Immune and inflammation transcriptomics quantification from ectopic endometriotic lesions and matched eutopic endometrium from patients. Endometria of fertile women served as control subjects. RESULT(S): Our results displayed endometriotic lesions as molecularly distinct entities compared with eutopic endometrium and endometrium of control samples; 396 out of 579 screened immune and inflammation-related genes were significantly different in ectopic tissues compared with control endometrium. Most importantly, eutopic endometrium of the patients displayed a unique molecular profile compared with the control endometrium (91/579 genes were significantly different), particularly of genes involved in regulation of cell apoptosis and decidualization. CONCLUSION(S): We characterize differential expression of immune-inflammation genes in endometriosis patients, and show molecular distinction of eutopic endometrium of patients compared with control fertile women.

Indexed as

TranscriptomeApoptosisCase-Control StudiesCell AdhesionChemotaxisCluster AnalysisCytokinesCytotoxicity, ImmunologicEndometriosisEndometriumFemaleGene Expression ProfilingGenetic MarkersHospitals, TeachingHumansInflammationCytokinesGenetic MarkersReceptors, CytokineAngiogenesisendometriosisimmune genesinfertilityinflammation

Identifiers

PMID27475412
PMCPMC5683404
OpenAlexW2478285889

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.