ArticleLancet (London, England)2016
The economic burden of physical inactivity: a global analysis of major non-communicable diseases.
Article in Lancet (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 958 papers, 17 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Home-based Exercise Gaming on Cardio-Metabolic and Cognitive Health Markers in Physically Inactive Individuals
Smartphone Based Health Behaviour Intervention for Adolescents; Usage and Daily Attrition Rates.
PACE - Physical Activity in COPD Using E-Health: Effectiveness of a Personalised eHealth Platform Integrated Into Pulmonary Rehabilitation to Increase Physical Activity in Patients With COPD - a Randomized Controlled Trial
Gender Impact On Physical Activity In Chronic Musculoskeletal Disorders Prevention: A Survey-based Cross-sectional Study in Regione Lombardia
Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial
Who cites it
958 citing papers in PubMed, 17 syntheses or guidelines pooled it, 2,177 citations in OpenAlex.
- Functional social support and physical activity in community-dwelling older adults: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- A critical systematic review of the impact of sedentarism and physical inactivity on the cognitive performance of children.Systematic reviews · 2026Pooled it
- Women's experiences of discussing health behaviours within their maternity care: a systematic review and meta-synthesis.Reproductive health · 2026Pooled it
- Effectiveness of moderate-to-low intensity exercise snacks on glucose and lipid metabolism in sedentary adults: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Effectiveness of outdoor fitness equipment intervention on health outcomes: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Effects of digital multimodal interventions on objectively measured physical activity in older adults: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Associations between the built environment and jogging behaviour based on voluntarily contributed tracking data: a systematic review and meta-analysis.International journal of health geographics · 2025Pooled it
- Digital technology integration in home-based exercise: a systematic review of research evolution, applications, and impact mechanisms.BMC public health · 2025Pooled it
- What makes community-based, multilevel physical activity promotion last? A systematic review with narrative synthesis on factors for sustainable implementation.Perspectives in public health · 2025Pooled it
- Exergame-Based Behavior Change Interventions for Promoting Physical Activity: Systematic Review and Meta-Analysis of Randomized Controlled Studies.Journal of medical Internet research · 2025Pooled it
- Effects of Exercise Snacks on Cardiometabolic Health and Body Composition in Adults: A Systematic Review and Meta-Analysis.Scandinavian journal of medicine & science in sports · 2025Pooled it
- Comparative efficacy and safety of anticoagulant therapies in coronary artery disease: a network meta-analysis of randomized controlled trials.BMC cardiovascular disorders · 2025Pooled it
- Prevalence of metabolic syndrome and its association with selected factors among people with psychiatric conditions in Ethiopia: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Pooled it
- Effect of family doctor contract services on non-communicable disease management among the elderly: a systematic review and meta-analysis.Frontiers in health services · 2025Pooled it
- Effects of low-carbohydrate diets, with and without caloric restriction, on inflammatory markers in adults: a systematic review and meta-analysis of randomized clinical trials.European journal of clinical nutrition · 2024Pooled it
- DE-PASS best evidence statement (BESt): determinants of adolescents' device-based physical activity and sedentary behaviour in settings: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- A Sustainable Lifestyle Intervention Among Office Workers: Cluster Randomized Pilot and Feasibility Study.JMIR formative research · 2026Trial
- Effectiveness and Cost-Effectiveness of an App-Based Mindfulness Breast Care Program for Reducing Body Image Distress and Stigma Among Survivors of Breast Cancer: Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- Physical activity coaching programme for people with Long COVID: a pilot randomised clinical trial.Scientific reports · 2026Trial
898 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pandemic of physical inactivity is associated with a range of chronic diseases and early deaths. Despite the well documented disease burden, the economic burden of physical inactivity remains unquantified at the global level. A better understanding of the economic burden could help to inform resource prioritisation and motivate efforts to increase levels of physical activity worldwide.
methodsDirect health-care costs, productivity losses, and disability-adjusted life-years (DALYs) attributable to physical inactivity were estimated with standardised methods and the best data available for 142 countries, representing 93·2% of the world's population. Direct health-care costs and DALYs were estimated for coronary heart disease, stroke, type 2 diabetes, breast cancer, and colon cancer attributable to physical inactivity. Productivity losses were estimated with a friction cost approach for physical inactivity related mortality. Analyses were based on national physical inactivity prevalence from available countries, and adjusted population attributable fractions (PAFs) associated with physical inactivity for each disease outcome and all-cause mortality.
findingsConservatively estimated, physical inactivity cost health-care systems international $ (INT$) 53·8 billion worldwide in 2013, of which $31·2 billion was paid by the public sector, $12·9 billion by the private sector, and $9·7 billion by households. In addition, physical inactivity related deaths contribute to $13·7 billion in productivity losses, and physical inactivity was responsible for 13·4 million DALYs worldwide. High-income countries bear a larger proportion of economic burden (80·8% of health-care costs and 60·4% of indirect costs), whereas low-income and middle-income countries have a larger proportion of the disease burden (75·0% of DALYs). Sensitivity analyses based on less conservative assumptions led to much higher estimates.
interpretationIn addition to morbidity and premature mortality, physical inactivity is responsible for a substantial economic burden. This paper provides further justification to prioritise promotion of regular physical activity worldwide as part of a comprehensive strategy to reduce non-communicable diseases.
fundingNone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.