Evidence map›Paper›PMID 27475266›Full record

ArticleLancet (London, England)2016

The economic burden of physical inactivity: a global analysis of major non-communicable diseases.

Ding Ding, Kenny D Lawson, Tracy L Kolbe-Alexander, Eric A Finkelstein, Peter T Katzmarzyk, Willem van Mechelen, Michael Pratt, Lancet Physical Activity Series 2 Executive Committee

5 registry-linked trialsAbstract readComment
PubMed Publisher
In one paragraph

Article in Lancet (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 958 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
958citing papers in PubMed, 17 pooled it
106.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04633590 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Home-based Exercise Gaming on Cardio-Metabolic and Cognitive Health Markers in Physically Inactive Individuals

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2022 to 2023Enrolled27ConditionsPhysical InactivityArmsHome-based exergaming
NCT05912439 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Smartphone Based Health Behaviour Intervention for Adolescents; Usage and Daily Attrition Rates.

TypeinterventionalSponsorUniversity of IcelandRan2017 to 2023Enrolled670ConditionsHealthy Adolescents in School-based PopulationArmsSidekickHealth
NCT06732869 narecruitingnot on this mapstarted 2024, after this paper: background citation

PACE - Physical Activity in COPD Using E-Health: Effectiveness of a Personalised eHealth Platform Integrated Into Pulmonary Rehabilitation to Increase Physical Activity in Patients With COPD - a Randomized Controlled Trial

TypeinterventionalSponsorInstituto Politécnico de LeiriaRan2024 to 2025Enrolled57ConditionsCOPD, Physical ActivityArmseHealth physical activity coaching intervention, pulmonary rehabilitation
NCT06747052 recruitingnot on this mapstarted 2025, after this paper: background citation

Gender Impact On Physical Activity In Chronic Musculoskeletal Disorders Prevention: A Survey-based Cross-sectional Study in Regione Lombardia

TypeobservationalSponsorI.R.C.C.S Ospedale Galeazzi-Sant'AmbrogioRan2025 to 2026Enrolled1,310ConditionsPhysical Activity, Musculoskeletal Disease, Gender Equity
NCT07119658 nacompletednot on this mapstarted 2025, after this paper: background citation

Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial

TypeinterventionalSponsorIndiana UniversityRan2025 to 2026Enrolled20ConditionsHypertension, Hyperglycemia, Dyslipidemia, Metabolic SyndromeArmsComposite intervention to address MetS
3 · Its place in the literature

Who cites it

958 citing papers in PubMed, 17 syntheses or guidelines pooled it, 2,177 citations in OpenAlex.

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898 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 6 countries.

Ding DingPrevention Research Collaboration/the Charles Perkins Centre, Sydney School of Public Health, The University of Sydney, Camperdown, NSW, Australia; Centre for Chronic Disease Prevention, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD, Australia. Electronic address: melody.ding@sydney.edu.au.
Kenny D LawsonCentre for Chronic Disease Prevention, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD, Australia; Centre for Health Research, School of Medicine, Western Sydney University, Sydney, NSW, Australia.
Tracy L Kolbe-AlexanderCentre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, QLD, Australia; Research Unit for Exercise Science and Sports Medicine (ESSM), Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Eric A FinkelsteinDuke University-National University of Singapore, Singapore.
Peter T KatzmarzykPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Willem van MechelenCentre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, QLD, Australia; Research Unit for Exercise Science and Sports Medicine (ESSM), Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Department of Public and Occupational Health and EMGO+ Institute, VU University Medical Center, Amsterdam, Netherlands; School of Public Health, Physiotherapy and Population Sciences, University College Dublin, Dublin, Ireland.
Michael PrattHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Lancet Physical Activity Series 2 Executive Committee
Emory University · USLouisiana State University · USNational University of Singapore · SGUniversity College Dublin · IEUniversity of Cape Town · ZAUniversity of Sydney · AUWestern Sydney University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pandemic of physical inactivity is associated with a range of chronic diseases and early deaths. Despite the well documented disease burden, the economic burden of physical inactivity remains unquantified at the global level. A better understanding of the economic burden could help to inform resource prioritisation and motivate efforts to increase levels of physical activity worldwide.

methodsDirect health-care costs, productivity losses, and disability-adjusted life-years (DALYs) attributable to physical inactivity were estimated with standardised methods and the best data available for 142 countries, representing 93·2% of the world's population. Direct health-care costs and DALYs were estimated for coronary heart disease, stroke, type 2 diabetes, breast cancer, and colon cancer attributable to physical inactivity. Productivity losses were estimated with a friction cost approach for physical inactivity related mortality. Analyses were based on national physical inactivity prevalence from available countries, and adjusted population attributable fractions (PAFs) associated with physical inactivity for each disease outcome and all-cause mortality.

findingsConservatively estimated, physical inactivity cost health-care systems international $ (INT$) 53·8 billion worldwide in 2013, of which $31·2 billion was paid by the public sector, $12·9 billion by the private sector, and $9·7 billion by households. In addition, physical inactivity related deaths contribute to $13·7 billion in productivity losses, and physical inactivity was responsible for 13·4 million DALYs worldwide. High-income countries bear a larger proportion of economic burden (80·8% of health-care costs and 60·4% of indirect costs), whereas low-income and middle-income countries have a larger proportion of the disease burden (75·0% of DALYs). Sensitivity analyses based on less conservative assumptions led to much higher estimates.

interpretationIn addition to morbidity and premature mortality, physical inactivity is responsible for a substantial economic burden. This paper provides further justification to prioritise promotion of regular physical activity worldwide as part of a comprehensive strategy to reduce non-communicable diseases.

fundingNone.

Indexed as

Diabetes Mellitus, Type 2Quality-Adjusted Life YearsChronic DiseaseCost of IllnessGlobal HealthHealth Care CostsHumansMortality, Premature

Identifiers

PMID27475266
OpenAlexW2493586185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.