Evidence map›Paper›PMID 27475089›Full record

ArticleBreast cancer research and treatment2016

Patterns of change over time and history of the inflammatory potential of diet and risk of breast cancer among postmenopausal women.

Fred K Tabung, Susan E Steck, Angela D Liese, Jiajia Zhang, Yunsheng Ma, Karen C Johnson, Dorothy S Lane, Lihong Qi, Linda Snetselaar, Mara Z Vitolins and 2 more

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Article in Breast cancer research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fred K TabungDepartments of Nutrition and Epidemiology, Harvard T. H. Chan School of Public Health, Boston, USA.
Susan E SteckCancer Prevention and Control Program, University of South Carolina, Columbia, USA. ssteck@sc.edu.
Angela D LieseDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, USA.
Jiajia ZhangDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, USA.
Yunsheng MaDivision of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, USA.
Karen C JohnsonDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, USA.
Dorothy S LaneDepartment of Family, Population and Preventive Medicine, Stony Brook University School of Medicine, New York, USA.
Lihong QiDivision of Biostatistics, Department of Public Health Sciences, University of California, Davis, USA.
Linda SnetselaarDepartment of Epidemiology, The University of Iowa, Iowa City, USA.
Mara Z VitolinsDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, USA.
Judith K OckeneDivision of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, USA.
James R HebertCancer Prevention and Control Program, University of South Carolina, Columbia, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Expanding Mentoring Capacity in High-Risk PopulationsK05CA136975 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HEBERT, JAMES R · 2009 to 2013
$801k
Dietary Inflammatory Index and Risk of Cancer in WomenF31CA177255 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TABUNG, FRED KINYUY · 2013 to 2013
$37k
NCI NIH HHS F31 CA177255NCI NIH HHS K05 CA136975NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

We utilized the dietary inflammatory index (DII) to investigate associations between patterns of change in, and history of the inflammatory potential of diet and risk of breast cancer in the Women's Health Initiative (WHI). We included 70,998 postmenopausal women aged 50-79 years recruited from 1993 to 1998 into the WHI Observational Study and Dietary Modification trial control group and followed through August 29, 2014. We utilized data from food frequency questionnaires administered at baseline and Year 3, to calculate average DII scores, patterns of change in DII, and used these measures in multivariable-adjusted Cox regression models to estimate hazards ratios (HR) and 95 % confidence intervals (CI) for incident invasive breast cancer and its subtypes. After 1,093,947 person-years of follow-up, 3471 cases of invasive breast cancer were identified. There was no substantial association between average DII scores or patterns of change in DII and risk of overall invasive breast cancer (HR, 1.03; 95 % CI, 0.90, 1.17; P-trend = 0.79; comparing extreme average DII quintiles). However, there was a significant nonlinear association between average DII scores and the ER-, PR-, HER2+, subtype (HR, 2.37; 95 % CI, 1.08, 5.20; P-trend = 0.18; comparing extreme quintiles). For patterns of change in DII, the age-adjusted association with ER-, PR-, HER2+ subtype comparing women in the proinflammatory stable to those in the anti-inflammatory stable categories (HR, 1.82; 95 % CI, 1.06, 3.13) persisted in the multivariable-adjusted model but was less precise (HR, 1.85; 95 % CI, 0.96, 3.55; P = 0.06). Dietary inflammatory potential may differentially influence the development of specific breast cancer phenotypes.

Indexed as

Feeding BehaviorAgedBreast NeoplasmsFemaleHumansInflammationMiddle AgedPostmenopauseSelf ReportBreast cancerDietDietary patternsEpidemiologyInflammation

Identifiers

PMID27475089
PMCPMC5609451

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.