ArticlePsychoneuroendocrinology2016
Acute cortisol reactivity attenuates engagement of fronto-parietal and striatal regions during emotion processing in negative mood disorders.
Article in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of Cortisol Administration on Resting-State Functional Connectivity in Women with Depression.Psychiatry research. Neuroimaging · 2024Trial
- Violence exposure moderates stress-elicited neurobehavioral function in young people.Emotion (Washington, D.C.) · 2026Article
- Mechanistic Underpinnings of Emotional Face Processing in Suicide Risk: Exploring the Moderating Effects of Cortisol on Neural Parameters Using Magnetoencephalography.Psychiatric research and clinical practice · 2026Article
- Research prospect of human salivary cortisol: a bibliometric analysis.Frontiers in psychology · 2025Review
- Case Report: Management of a patient with Sheehan's syndrome presenting with anxiety and depression.Frontiers in endocrinology · 2025Article
- Effect of Tai Chi on Young Adults with Subthreshold Depression via a Stress-Reward Complex: A Randomized Controlled Trial.Sports medicine - open · 2023Article
- Neighborhood social cohesion and serious psychological distress among Asian, Black, Hispanic/Latinx, and White adults in the United States: a cross-sectional study.BMC public health · 2022Article
- Graph Theory Analysis of the Cortical Functional Network During Sleep in Patients With Depression.Frontiers in physiology · 2022Article
- A voxel-level brain-wide association study of cortisol at 8 a.m.: Evidence from Cushing's disease.Neurobiology of stress · 2021Article
- The relationship between cortisol reactivity and emotional brain function is differently moderated by childhood trauma, in bipolar disorder, schizophrenia and healthy individuals.European archives of psychiatry and clinical neuroscience · 2021Article
- Individual differences in pain sensitivity in drug-naive patients with major depressive disorder: an fMRI study.Brain imaging and behavior · 2021Article
- The Role of Endocrine Stress Systems and Sex Hormones in the Enhancing Effects of Stress on Mental Rotation Capabilities.Brain sciences · 2020Article
- The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress.Neuropsychiatric disease and treatment · 2020Review
- Pre-scan cortisol is differentially associated with enhanced connectivity to the cognitive control network in young adults with a history of depression.Psychoneuroendocrinology · 2019Article
- Translational Functional Neuroimaging in the Explanation of Depression.Balkan medical journal · 2017Review
- Redefining the endophenotype concept to accommodate transdiagnostic vulnerabilities and etiological complexity.Biomarkers in medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveDepression and bipolar disorder (negative mood disorders, NMD) are associated with dysregulated hypothalamic-pituitary-adrenal (HPA)-axis function and disrupted emotion processing. The neural networks involved in attenuation of HPA-axis reactivity overlap with the circuitry involved in perception and modulation of emotion; however, direct links between these systems are understudied. This study investigated whether cortisol activity prior to undergoing fMRI was related to neural processing of emotional information in participants with NMD.
methodsForty-one adults (M
resultsOverall, pre-scan cortisol level was positively associated with greater engagement of the dorsal anterior cingulate (dACC), inferior parietal lobule, insula, putamen, precuneus, middle and medial frontal and postcentral gyri, posterior cingulate, and inferior temporal gyrus during emotion processing of all faces. NMD status moderated this effect; in NMD participants' pre-scan cortisol was associated with attenuated activation of the insula, postcentral gyrus, precuneus, and putamen for fearful faces and the medial frontal gyrus for angry faces relative to HCs. Cortisol-related attenuation of activation among NMD participants was also observed for facial identification in the dACC, putamen, middle temporal gyrus, precuneus, and caudate.
conclusionsAcross all participants, cortisol was associated with greater activation in several regions involved in the perception and control of emotion. However, cortisol responsivity was associated with hypoactivation of several of these regions in the NMD group, suggesting that HPA-axis activity may selectively interfere with the potentially adaptive recruitment of circuits supporting emotion perception, processing and/or regulation in mood disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.