Evidence map›Paper›PMID 27474806›Full record

ReviewCurrent opinion in cell biology2016

Live imaging of stem cells: answering old questions and raising new ones.

Sangbum Park, Valentina Greco, Katie Cockburn

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Stem Cell Niche Concept: Search for Current Expert Consensus.International journal of molecular sciences · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. ACS nano · 2019
    Article
  14. Article
  15. A Regeneration Toolkit.Developmental cell · 2018
    Review
  16. Review
  17. Homeostasis, regeneration and tumour formation in the mammalian epidermis.The International journal of developmental biology · 2018
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sangbum ParkDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.
Valentina GrecoDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Departments of Dermatology & Cell Biology, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: valentina.greco@yale.edu.
Katie CockburnDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: katherine.cockburn@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Live Imaging of Skin RegenerationR01AR063663 · NIAMS · YALE UNIVERSITY · PI Valentina Greco · 2012 to 2026
$7.7M
Normal stem cells and their transition to disease in the skinR01AR067755 · NIAMS · YALE UNIVERSITY · PI GRECO, VALENTINA · 2016 to 2020
$2.2M
CIHRNCATS NIH HHS UL1 TR001863NIAMS NIH HHS R01 AR063663NIAMS NIH HHS R01 AR067755
6 · The paper itself

Abstract

Stem cells are essential for both tissue maintenance and injury repair, but many aspects of stem cell biology remain incompletely understood. Recent advances in live imaging technology have allowed the direct visualization and tracking of a wide variety of tissue-resident stem cells in their native environments over time. Results from these studies have helped to resolve long-standing debates about stem cell regulation and function while also revealing previously unanticipated phenomena that raise new questions for future work. Here we review recent discoveries of both types, with a particular emphasis on how stem cells behave and interact with their niches during homeostasis, as well as how these behaviours change in response to wounding.

Indexed as

Imaging, Three-DimensionalAnimalsCarcinogenesisCell ProliferationHumansStem Cell NicheStem CellsWound Healing

Identifiers

PMID27474806
PMCPMC5154884

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.