ArticleGenetics2016
Fine-Scale Human Population Structure in Southern Africa Reflects Ecogeographic Boundaries.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Evaluating classification approaches for population affinity estimation in a contemporary South African CT-derived sample: an automatic landmarking-based approach.International journal of legal medicine · 2026Article
- Recovering the precolonial population structure of Khoe-San descendant populations.Science advances · 2026Article
- Article
- Common DNA sequence variation influences epigenetic aging in African populations.Communications biology · 2025Article
- Recovering the pre-colonial population structure of Khoe-San descendant populations.bioRxiv : the preprint server for biology · 2025Article
- The Indian Ocean slave trade and colonial expansion resulted in strong sex-biased admixture in South Africa.American journal of human genetics · 2025Article
- High resolution class I HLA-A, -B, and -C diversity in Eastern and Southern African populations.Scientific reports · 2025Article
- Persistence of Ancestral KhoeSan Mitochondrial Patterns in Contemporary South African Populations.Annals of human genetics · 2025Article
- Article
- AncestryGrapher toolkit: Python command-line pipelines to visualize global- and local- ancestry inferences from the RFMIX version 2 software.Bioinformatics (Oxford, England) · 2024Article
- 9,000 years of genetic continuity in southernmost Africa demonstrated at Oakhurst rockshelter.Nature ecology & evolution · 2024Article
- Strong effect of demographic changes on Tuberculosis susceptibility in South Africa.PLOS global public health · 2024Article
- Whole genomes from Angola and Mozambique inform about the origins and dispersals of major African migrations.Nature communications · 2023Article
- Genome-wide variation in the Angolan Namib Desert reveals unique pre-Bantu ancestry.Science advances · 2023Article
- Identifying genetic loci that are associated with changes in gene expression in PTSD in a South African cohort.Journal of neurochemistry · 2023Article
- Low and differential polygenic score generalizability among African populations due largely to genetic diversity.HGG advances · 2023Article
- Evolutionary Genetics and Admixture in African Populations.Genome biology and evolution · 2023Review
- Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa.American journal of human genetics · 2022Article
- The recombination landscape of the Khoe-San likely represents the upper limits of recombination divergence in humans.Genome biology · 2022Article
- Genomic analysis reveals geography rather than culture as the predominant factor shaping genetic variation in northern Kenyan human populations.American journal of biological anthropology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Recent genetic studies have established that the KhoeSan populations of southern Africa are distinct from all other African populations and have remained largely isolated during human prehistory until ∼2000 years ago. Dozens of different KhoeSan groups exist, belonging to three different language families, but very little is known about their population history. We examine new genome-wide polymorphism data and whole mitochondrial genomes for >100 South Africans from the ≠Khomani San and Nama populations of the Northern Cape, analyzed in conjunction with 19 additional southern African populations. Our analyses reveal fine-scale population structure in and around the Kalahari Desert. Surprisingly, this structure does not always correspond to linguistic or subsistence categories as previously suggested, but rather reflects the role of geographic barriers and the ecology of the greater Kalahari Basin. Regardless of subsistence strategy, the indigenous Khoe-speaking Nama pastoralists and the N|u-speaking ≠Khomani (formerly hunter-gatherers) share ancestry with other Khoe-speaking forager populations that form a rim around the Kalahari Desert. We reconstruct earlier migration patterns and estimate that the southern Kalahari populations were among the last to experience gene flow from Bantu speakers, ∼14 generations ago. We conclude that local adoption of pastoralism, at least by the Nama, appears to have been primarily a cultural process with limited genetic impact from eastern Africa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.