ReviewExperimental physiology2016
Temporal partitioning of cardiac metabolism by the cardiomyocyte circadian clock.
Review in Experimental physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Review
- Seasonality of Selected Cardiovascular Disorders in Austria: A Retrospective Observational Study Between 2009 and 2023.Journal of the American Heart Association · 2026Observational
- The metabolic significance of peripheral tissue clocks.Communications biology · 2025Review
- Circadian biology of cardiac aging.Journal of molecular and cellular cardiology · 2025Review
- Leveraging chromatin state transitions for the identification of regulatory networks orchestrating heart regeneration.Nucleic acids research · 2024Article
- Prognostic utility of rhythmic components in 24-h ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity.Journal of human hypertension · 2024Article
- Circadian Rhythms in Cardiovascular Metabolism.Circulation research · 2024Review
- Article
- The interplay between sex, time of day, fasting status, and their impact on cardiac mitochondrial structure, function, and dynamics.Scientific reports · 2023Article
- Time-restricted feeding regulates lipid metabolism under metabolic challenges.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Review
- The Cardiac Circadian Clock: Implications for Cardiovascular Disease and its Treatment.JACC. Basic to translational science · 2023Review
- Multitissue Circadian Proteome Atlas of WT and Per1Molecular & cellular proteomics : MCP · 2023Article
- Circadian Rhythms in Cardiovascular Function: Implications for Cardiac Diseases and Therapeutic Opportunities.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- The Circadian Biology of Heart Failure.Circulation research · 2023Review
- Circadian Governance of Cardiac Growth.Cells · 2022Review
- Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational Aspects.Circulation. Arrhythmia and electrophysiology · 2021Review
- Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology.Nature communications · 2021Article
- Branched chain amino acids selectively promote cardiac growth at the end of the awake period.Journal of molecular and cellular cardiology · 2021Article
- Impact of obesity on day-night differences in cardiac metabolism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Re-balancing cellular energy substrate metabolism to mend the failing heart.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
NEW
findingsWhat is the topic of this review? This review highlights temporal partitioning of cardiac metabolism by the cardiomyocyte circadian clock. What advances does it highlight? Advances include: 1) cardiac glucose utilization peaks during the active period to meet increased energetic demands at this time; 2) synthesis of glycogen and triglyceride peak in the heart during the latter half of the active period, likely in anticipation of the upcoming sleep/fasting period; and 3) protein turnover increases in the heart at the beginning of the sleep phase, probably to promote growth and repair at this time. Cell-autonomous circadian clocks have emerged as crucial mediators of 24 h rhythms in cellular processes. In doing so, these molecular timekeepers confer the selective advantage of anticipation, allowing cells and organs to prepare for stimuli and stresses before their onset. The heart is subjected to dramatic fluctuations in energetic demand and nutrient supply in association with sleep-wake and fasting-feeding cycles. Recent studies suggest that the cardiomyocyte circadian clock orchestrates daily rhythms in both oxidative and non-oxidative glucose and fatty acid metabolism, as well as protein turnover. Here, I review this evidence and discuss whether disruption of these rhythms can contribute to cardiovascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.