Evidence map›Paper›PMID 27473936›Full record

ReviewNeuroscience and biobehavioral reviews2016

Stress and the adolescent brain: Amygdala-prefrontal cortex circuitry and ventral striatum as developmental targets.

Nim Tottenham, Adriana Galván

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  6. A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022
    Pooled it
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  18. Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026
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  20. Review

108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nim TottenhamColumbia University, Department of Psychology, 1190 Amsterdam Avenue MC 5501, New York, NY 10027, United States. Electronic address: nlt7@columbia.edu.
Adriana GalvánUniversity of California, Los Angeles, Department of Psychology, 1285 Franz Hall BOX 951563, Los Angeles, CA 90095-1563, United States. Electronic address: agalvan@ucla.edu.

Funding

Predicting Heterogeneous Neurodevelopmental Outcomes in School-age Children with Early Caregiving AdversitiesR01MH091864 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MILHAM, MICHAEL PETER, TOTTENHAM, NIM · 2010 to 2022
$5.1M
NIMH NIH HHS R01 MH091864
6 · The paper itself

Abstract

Adolescence is a time in development when significant changes occur in affective neurobiology. These changes provide a prolonged period of plasticity to prepare the individual for independence. However, they also render the system highly vulnerable to the effects of environmental stress exposures. Here, we review the human literature on the associations between stress-exposure and developmental changes in amygdala, prefrontal cortex, and ventral striatal dopaminergic systems during the adolescent period. Despite the vast differences in types of adverse exposures presented in his review, these neurobiological systems appear consistently vulnerable to stress experienced during development, providing putative mechanisms to explain why affective processes that emerge during adolescence are particularly sensitive to environmental influences.

Indexed as

AmygdalaPrefrontal CortexStress, PhysiologicalVentral StriatumAdolescentHumansNeurobiologyAdolescenceAmygdalaHumanPrefrontal cortexStressVentral striatum

Identifiers

PMID27473936
PMCPMC5074883

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.