ArticleAmerican journal of clinical pathology2016
Challenges of Maintaining Good Clinical Laboratory Practices in Low-Resource Settings: A Health Program Evaluation Framework Case Study From East Africa.
Article in American journal of clinical pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Simulation modeling for the design and evaluation of HIV drug resistance interventions: a systematic review of literature.BMC public health · 2026Pooled it
- Determinants of quality laboratory service provision amongst government comprehensive specialized hospitals in Northwest Ethiopia.Health research policy and systems · 2026Article
- Urgent Call for Action: Bridging Gaps in Asia-Pacific Laboratories' Transition to ISO 15189:2022.EJIFCC · 2026Article
- Building genomic capacity for precision health in Africa.Nature medicine · 2024Review
- Evaluation of Laboratories Supporting Invasive Bacterial Vaccine-Preventable Disease (IB-VPD) Surveillance in the World Health Organization African Region, through the Performance of Coordinated External Quality Assessment.Tropical medicine and infectious disease · 2023Article
- Biocatalytic synthesis of 2'-deoxynucleotide 5'-triphosphates from bacterial genomic DNA: Proof of principle.Biotechnology and bioengineering · 2023Article
- Developing capacity for implementation and evaluation of vaccine trials in Uganda: Perspective of the Makerere University Walter Reed Project.African health sciences · 2022Article
- Preparedness of district clinical laboratories towards ISO 15189: 2012 accreditation scheme in Lake Zone, Tanzania (a descriptive cross-sectional study).The Pan African medical journal · 2022Article
- Clinical diagnosis in paediatric patients at urban primary health care facilities in southern Malawi: a longitudinal observational study.BMC health services research · 2021Observational
- Setting up a molecular diagnostic laboratory for SARS-CoV-2 testing: Experience of a single centre in a resource-constrained setting.African journal of laboratory medicine · 2021Article
- Hematological malignancies in East Africa-Which cancers to expect and how to provide services.PloS one · 2020Article
- DNA amplification with in situ nucleoside to dNTP synthesis, using a single recombinant cell lysate of E. coli.Scientific reports · 2019Article
- Toward Improving Accessibility of Point-of-Care Diagnostic Services for Maternal and Child Health in Low- and Middle-Income Countries.Point of care · 2019Article
- Cellular reagents for diagnostics and synthetic biology.PloS one · 2018Article
- Design and Implementation of the Retinoblastoma Collaborative Laboratory.Ocular oncology and pathology · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesUsing a clinical research laboratory as a case study, we sought to characterize barriers to maintaining Good Clinical Laboratory Practice (GCLP) services in a developing world setting.
methodsUsing a US Centers for Disease Control and Prevention framework for program evaluation in public health, we performed an evaluation of the Kilimanjaro Christian Medical Centre-Duke University Health Collaboration clinical research laboratory sections of the Kilimanjaro Clinical Research Institute in Moshi, Tanzania. Laboratory records from November 2012 through October 2014 were reviewed for this analysis.
resultsDuring the 2-year period of study, seven instrument malfunctions suspended testing required for open clinical trials. A median (range) of 9 (1-55) days elapsed between instrument malfunction and biomedical engineer service. Sixteen (76.1%) of 21 suppliers of reagents, controls, and consumables were based outside Tanzania. Test throughput among laboratory sections used a median (range) of 0.6% (0.2%-2.7%) of instrument capacity. Five (55.6%) of nine laboratory technologists left their posts over 2 years.
conclusionsThese findings demonstrate that GCLP laboratory service provision in this setting is hampered by delays in biomedical engineer support, delays and extra costs in commodity procurement, low testing throughput, and high personnel turnover.
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