ReviewInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2017
Endophenotype best practices.
Review in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth.Current neuropharmacology · 2025Pooled it
- Same dose, different impact: acute cannabis intoxication impairs visuospatial working memory in both sexes, with disproportionate male vulnerability.Frontiers in behavioral neuroscience · 2026Article
- Article
- Faster bi-stable visual switching in psychosis.Translational psychiatry · 2024Article
- Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood.Psychological medicine · 2024Article
- Endophenotype trait domains for advancing gene discovery in autism spectrum disorder.Journal of neurodevelopmental disorders · 2023Review
- The psychosis human connectome project: Design and rationale for studies of visual neurophysiology.NeuroImage · 2023Article
- Longitudinal stability and change in time-frequency measures from an oddball task during adolescence and early adulthood.Psychophysiology · 2023Article
- Genetic and environmental etiology of drinking motives in college students.Alcoholism, clinical and experimental research · 2022Article
- Associating complex traits with genetic variants: polygenic risk scores, pleiotropy and endophenotypes.Genetica · 2022Article
- Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?Frontiers in psychology · 2022Review
- What Has Been Learned from Using EEG Methods in Research of ADHD?Current topics in behavioral neurosciences · 2022Article
- Orbitofrontal cortex thickness and substance use disorders in emerging adulthood: causal inferences from a co-twin control/discordant twin study.Addiction (Abingdon, England) · 2021Article
- The Effects of Alcohol and Cannabis Use on the Cortical Thickness of Cognitive Control and Salience Brain Networks in Emerging Adulthood: A Co-twin Control Study.Biological psychiatry · 2021Article
- Forgetting Unwanted Memories: Active Forgetting and Implications for the Development of Psychological Disorders.Journal of personalized medicine · 2021Review
- Transcriptome-wide association study reveals two genes that influence mismatch negativity.Cell reports · 2021Article
- Parietal P3 and midfrontal theta prospectively predict the development of adolescent alcohol use.Psychological medicine · 2021Article
- Precision Psychiatry: Biomarker-Guided Tailored Therapy for Effective Treatment and Prevention in Major Depression.Advances in experimental medicine and biology · 2021Review
- Validating Online Measures of Cognitive Ability in Genes for Good, a Genetic Study of Health and Behavior.Assessment · 2020Article
- Minnesota Center for Twin and Family Research.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
This review examines the current state of electrophysiological endophenotype research and recommends best practices that are based on knowledge gleaned from the last decade of molecular genetic research with complex traits. Endophenotype research is being oversold for its potential to help discover psychopathology relevant genes using the types of small samples feasible for electrophysiological research. This is largely because the genetic architecture of endophenotypes appears to be very much like that of behavioral traits and disorders: they are complex, influenced by many variants (e.g., tens of thousands) within many genes, each contributing a very small effect. Out of over 40 electrophysiological endophenotypes covered by our review, only resting heart, a measure that has received scant advocacy as an endophenotype, emerges as an electrophysiological variable with verified associations with molecular genetic variants. To move the field forward, investigations designed to discover novel variants associated with endophenotypes will need extremely large samples best obtained by forming consortia and sharing data obtained from genome wide arrays. In addition, endophenotype research can benefit from successful molecular genetic studies of psychopathology by examining the degree to which these verified psychopathology-relevant variants are also associated with an endophenotype, and by using knowledge about the functional significance of these variants to generate new endophenotypes. Even without molecular genetic associations, endophenotypes still have value in studying the development of disorders in unaffected individuals at high genetic risk, constructing animal models, and gaining insight into neural mechanisms that are relevant to clinical disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.