ArticleBMC complementary and alternative medicine2016
Hepatoprotective activity of ethanolic extract of Salix subserrata against CCl4-induced chronic hepatotoxicity in rats.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Phenolic Compounds Isolated fromMolecules (Basel, Switzerland) · 2026Article
- Hepatoprotective potential of Urochloa distachya (L.) ethanol extract against paracetamol and CClInflammopharmacology · 2026Article
- Exploring antimicrobial properties and oral health benefits of salix subserrata willd: unveiling the potential beyond its use as traditional chewing stick.BMC complementary medicine and therapies · 2025Article
- Hepatoprotective Potential ofCurrent drug discovery technologies · 2025Review
- Phytochemical and Bioactivity Evaluation of Bee Pollen and Androecia ofAntioxidants (Basel, Switzerland) · 2024Article
- Exploring the antioxidant and protective effects ofFrontiers in pharmacology · 2024Article
- Ethanolic Extract ofJournal of toxicology · 2024Article
- The protective effects of nerol to prevent the toxicity of carbon tetrachloride to the liver in Sprague-Dawley rats.Heliyon · 2023Article
- Evaluation of egg white hydrolysates on the hepatoprotective effect in vitro and in vivo.Journal of food science and technology · 2023Article
- Evaluation of Hepatoprotective Potential of Polyherbal Preparations in CClAdvances in pharmacological and pharmaceutical sciences · 2022Article
- Effect of silymarin on blood coagulation profile and osmotic fragility in carbon tetrachloride induced hepatotoxicity in male Wistar rats.Toxicology reports · 2022Article
- The potential effect of phytochemicals and herbal plant remedies for treating drug-induced hepatotoxicity: a review.Molecular biology reports · 2021Review
- Phytochemistry, Pharmacology and Medicinal Uses of Plants of the GenusFrontiers in pharmacology · 2021Review
- Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction.Molecules (Basel, Switzerland) · 2020Review
- A study of the hepatoprotective effect of Plantago psyllium L. seed extract against Carbon tetrachloride induced hepatic injury in rats.Journal of applied biomedicine · 2020Article
- Article
- Petroselinum sativum protects HepG2 cells from cytotoxicity and oxidative stress induced by hydrogen peroxide.Molecular biology reports · 2020Article
- Phenolic Compounds fromMolecules (Basel, Switzerland) · 2019Article
- The potential protective effect of two actinomycete extracts against carbon tetrachloride-induced hepatotoxicity in rats.Environmental science and pollution research international · 2019Article
- Protective effects ofWorld journal of gastroenterology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe liver performs diverse functions that are essential for life. In the absence of reliable liver protective drugs, a large number of natural medicinal preparations are used for the treatment of liver diseases. Therefore the present study aims to investigate the hepatoprotective effects of Salix subserrata Willd flower ethanolic extract (SFEE) against carbon tetrachloride (CCl4)-induced liver damage.
methodsRats were divided into 4 groups of 10 animals each. Group I served as the normal healthy control, groups II rats were intoxicated with CCl4 i.p. (0.8 ml/kg body weight CCl4/olive oil, twice weekly for 9 weeks), group III rats received CCl4 i.p. and SFEE orally (150 mg/kg daily) and group IV rats received CCl4 i.p. and Silymarin orally (100 mg/kg, daily). The hepatoprotective potential of SFEE in rats was evaluated by measuring the protein levels of two inflammatory biomarkers; tumor necrosis factor-alpha (TNF-α) and nuclear factor kappa-B (NF-kB) in addition to other liver biomarkers. Histopathological changes in the liver were assessed using hematoxylin and eosin staining (HE).
resultsThe administration of SFEE showed hepatic protection at an oral dose of 150 mg/kg. SFEE significantly reduced the elevated serum levels of intracellular liver enzymes as well as liver biomarkers in comparison to CCl4- intoxicated group. Notably, SFEE significantly reduced the expression levels of TNF-α and NFkB proteins compared to their levels in CCl4 intoxicated group. These findings were confirmed with the histopathological observations, where SFEE was capable of reversing the toxic effects of CCl4 on liver cells compared to that observed in CCl4-intoxicated animals.
conclusionOur results show that SFEE has potential hepatoprotective effects at 150 mg/kg. These effects can be regarded to the antioxidant and anti-inflammatory properties of the extract.
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