ArticleCerebral cortex (New York, N.Y. : 1991)2017
Retrosplenial Cortical Neurons Encode Navigational Cues, Trajectories and Reward Locations During Goal Directed Navigation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed.
- Preferred visual experiences provide intuitive descriptions of the functional properties of the cortical navigation network.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal theta sweeps indicate goal direction during navigation.Nature neuroscience · 2026Article
- Fibronectin1-Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.eLife · 2026Article
- A transparent wheel-based platform for locomotion-on-demand and multi-view body and facial kinematics in head-fixed mice.Scientific reports · 2026Article
- Anterior and posterior retrosplenial cortex form distinct visuospatial circuits in the mouse.Nature communications · 2026Article
- Place field dynamics in retrosplenial cortex compared to hippocampus.Progress in neurobiology · 2026Article
- Article
- Unique Transcriptomic Cell Types of the Granular Retrosplenial Cortex Are Preserved across Mice and Rats despite Dramatic Changes in Key Marker Genes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Combinative Protein Expression of Immediate Early Genes c-Fos, Arc, and Npas4 Along Aversive and Appetitive Experience-Related Neural Networks.Hippocampus · 2025Article
- Basal Forebrain Projections to the Retrosplenial and Cingulate Cortex in Rats.The Journal of comparative neurology · 2025Article
- The retrosplenial cortical role in delayed spatial alternation.Neurobiology of learning and memory · 2024Article
- Neural circuits for goal-directed navigation across species.Trends in neurosciences · 2024Review
- Egocentric neural representation of geometric vertex in the retrosplenial cortex.Nature communications · 2024Article
- Learning to use landmarks for navigation amplifies their representation in retrosplenial cortex.bioRxiv : the preprint server for biology · 2024Article
- Differential stability of task variable representations in retrosplenial cortex.Nature communications · 2024Article
- Hierarchical Gradients of Encoded Spatial and Sensory Information in the Neocortex Are Attenuated by Dorsal Hippocampal Lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The Retrosplenial Cortical Role in Delayed Spatial Alternation.bioRxiv : the preprint server for biology · 2024Article
- Space wandering in the rodent default mode network.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning.Brain structure & function · 2024Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
The retrosplenial cortex (RSC) plays an important role in memory and spatial navigation. It shares functional similarities with the hippocampus, including the presence of place fields and lesion-induced impairments in spatial navigation, and the RSC is an important source of visual-spatial input to the hippocampus. Recently, the RSC has been the target of intense scrutiny among investigators of human memory and navigation. fMRI and lesion data suggest an RSC role in the ability to use landmarks to navigate to goal locations. However, no direct neurophysiological evidence of encoding navigational cues has been reported so the specific RSC contribution to spatial cognition has been uncertain. To examine this, we trained rats on a T-maze task in which the reward location was explicitly cued by a flashing light and we recorded RSC neurons as the rats learned. We found that RSC neurons rapidly encoded the light cue. Additionally, RSC neurons encoded the reward and its location, and they showed distinct firing patterns along the left and right trajectories to the goal. These responses may provide key information for goal-directed navigation, and the loss of these signals may underlie navigational impairments in subjects with RSC damage.
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Registered trials
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