ArticleThe international journal of cardiovascular imaging2016
Caffeine intake inverts the effect of adenosine on myocardial perfusion during stress as measured by T1 mapping.
Article in The international journal of cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04585854 (Effect of Caffeine on Myocardial Oxygenation), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Caffeine on Myocardial Oxygenation
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- CMR T1 reactivity in healthy adult hearts: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Advances in Myocardial Perfusion MR Imaging: Physiological Implications, the Importance of Quantitative Analysis, and Impact on Patient Care in Coronary Artery Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Pooled it
- Repeatability of fully automated, inline quantitative assessment of myocardial perfusion in patients with suspected coronary artery disease.European heart journal. Imaging methods and practice · 2024Article
- Compact MR-compatible ergometer and its application in cardiac MR under exercise stress: A preliminary study.Magnetic resonance in medicine · 2022Article
- Ferumoxytol-enhanced magnetic resonance T1 reactivity for depiction of myocardial hypoperfusion.NMR in biomedicine · 2021Article
- Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods.Scientific reports · 2021Article
- A comparison of standard and high dose adenosine protocols in routine vasodilator stress cardiovascular magnetic resonance: dosage affects hyperaemic myocardial blood flow in patients with severe left ventricular systolic impairment.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Molecular Mechanisms of Adenosine Stress T1 Mapping.Circulation. Cardiovascular imaging · 2021Article
- Deep learning with attention supervision for automated motion artefact detection in quality control of cardiac T1-mapping.Artificial intelligence in medicine · 2020Article
- Clinical assessment of adenosine stress and rest cardiac magnetic resonance T1 mapping for detecting ischemic and infarcted myocardium.Scientific reports · 2020Article
- MRI perfusion in patients with stable chest-pain.The British journal of radiology · 2020Review
- Comparison of MOLLI and ShMOLLI in Terms of T1 Reactivity and the Relationship between T1 Reactivity and Conventional Signs of Response during Adenosine Stress Perfusion CMRBalkan medical journal · 2020Article
- Computed tomography for myocardial characterization in ischemic heart disease: a state-of-the-art review.European radiology experimental · 2020Review
- The reliability and feasibility of non-contrast adenosine stress cardiovascular magnetic resonance T1 mapping in patients on haemodialysis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Article
- Stress T1-mapping cardiovascular magnetic resonance imaging and inducible myocardial ischemia.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- T1 reactivity as an imaging biomarker in myocardial tissue characterization discriminating normal, ischemic and infarcted myocardium.The international journal of cardiovascular imaging · 2019Article
- Fully automated, inline quantification of myocardial blood flow with cardiovascular magnetic resonance: repeatability of measurements in healthy subjects.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018Article
- Disagreement between splenic switch-off and myocardial T1-mapping after caffeine intake.The international journal of cardiovascular imaging · 2018Article
- Gadolinium-Free Cardiac MR Stress T1-Mapping to Distinguish Epicardial From Microvascular Coronary Disease.Journal of the American College of Cardiology · 2018Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caffeine intake before adenosine stress myocardial perfusion imaging may cause false negative findings. We hypothesized that the antagonistic effect of caffeine can be measured by T1 relaxation times in rest and adenosine stress cardiac magnetic resonance imaging (CMR), as T1 mapping techniques are sensitive to changes in myocardial blood volume. We prospectively analyzed 105 consecutive patients with adenosine stress perfusion CMR on a 1.5-T MRI system. Rest and stress T1 mapping was performed using Modified Look-Locker Inversion recovery. T1 reactivity was defined as difference in T1rest and T1stress (∆T1). Fifteen patients drank coffee within 4 h of CMR (<4H caffeine group), and 10 patients had coffee the day before (>8H caffeine group). Comparison was made to patients without self-reported coffee intake: 50 with normal CMR (control group), 18 with myocardial ischemia, and 12 with myocardial infarction. The national review board approved the study; all patients gave written informed consent. The <4H caffeine group showed inverted ∆T1 of -7.8 % (T1rest 975 ± 42 ms, T1stress 898 ± 51 ms, p < 0.0005). The >8H caffeine group showed reduced T1 reactivity (1.8 %; T1rest 979 ms, T1stress 997 ms) compared to the controls (4.3 %; T1rest 977 ± 40 ms, T1stress 1018 ± 40 ms), p < 0.0005. Ischemic and infarcted myocardium showed minimal T1 reactivity (0.2 and 0.3 %, respectively). Caffeine intake inverts the adenosine effect during stress perfusion CMR as measured by T1 mapping. T1 reactivity can assess the adequacy of adenosine-induced stress in perfusion CMR.
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