Evidence map›Paper›PMID 27473155›Full record

ArticleInternational urology and nephrology2016

Lowering dialysate sodium improves systemic oxidative stress in maintenance hemodialysis patients.

Beyza Macunluoglu, Hasan Ali Gumrukcuoglu, Aydin Atakan, Halit Demir, Hamit Hakan Alp, Aytac Akyol, Serkan Akdag, Ahmet Yavuz, Zehra Eren, Sıddık Keskin and 1 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07459348 (Can Changes in Dialysate Sodium Concentration Improve Blood Pressure and Endothelial Function in Patients Undergoing Chronic Hemodialysis?), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07459348 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Can Changes in Dialysate Sodium Concentration Improve Blood Pressure and Endothelial Function in Patients Undergoing Chronic Hemodialysis?

TypeinterventionalSponsorGødstrup HospitalRan2026 to 2029Enrolled25ConditionsDialysis Dependent Chronic Kidney Disease, Dialysis Patients, Sodium Excess, High Blood PressureArmsLow-Sodium Dialysate (133 mmol/L), Standard-Sodium Dialysate (139 mmol/L)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Oxidative Stress in Kidney Diseases: The Cause or the Consequence?Archivum immunologiae et therapiae experimentalis · 2018
    Review
  5. Review
  6. Oxidative Stress in Hemodialysis Patients: A Review of the Literature.Oxidative medicine and cellular longevity · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Beyza MacunluogluDepartment of Nephrology, Uskudar State Hospital, 34000, Istanbul, Turkey.
Hasan Ali GumrukcuogluDepartment of Cardiology, Yuzuncu Yil University, 65200, Van, Turkey.
Aydin AtakanDepartment of Nephrology, Fatih Sultan Mehmet Training Hospital, 34000, Istanbul, Turkey.
Halit DemirDepartment of Biochemistry, Yuzuncu Yil University, 65200, Van, Turkey.
Hamit Hakan AlpDepartment of Biochemistry, Yuzuncu Yil University, 65200, Van, Turkey.
Aytac AkyolDepartment of Cardiology, Yuzuncu Yil University, 65200, Van, Turkey.
Serkan AkdagDepartment of Cardiology, Yuzuncu Yil University, 65200, Van, Turkey.
Ahmet YavuzDepartment of Nephrology, Kartal Training Hospital, 34890, Istanbul, Turkey.
Zehra ErenDepartment of Nephrology, Yeditepe University, 34890, Istanbul, Turkey.
Sıddık KeskinDepartment of Biostatistics, Yuzuncu Yil University, 65000, Van, Turkey.
Elif AriDepartment of Nephrology, Kartal Training Hospital, 34890, Istanbul, Turkey. elifaribakir@gmail.com.ORCID http://orcid.org/0000-0001-9208-7972
Van Yüzüncü Yıl Üniversitesi · TRFatih Sultan Mehmet Eğitim Ve Araştırma Hastanesi · TRŞişli Etfal Eğitim ve Araştırma Hastanesi · TRÜsküdar University · TRYeditepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of the current prospective study was to evaluate the effects of low sodium dialysate on oxidative stress parameters, blood pressure (BP) and endothelial dysfunction in maintenance hemodialysis (HD) patients.

methodsAfter baseline measurements were taken, the dialysate sodium concentration was reduced from 140 to 137 mEq/L. Oxidative stress parameters and flow-mediated dilatation (FMD %) were measured before and after 6 months of HD with low sodium dialysate. Interdialytic weight gain (IDWG) and pre- and post-dialysis BP were monitored during the study.

resultsA total of 52 patients were enrolled and 41 patients completed the study. There was a significant reduction in systolic blood pressure at the end of the study [130.00 (90.00-190.00) vs. 120.00 (90.00-150.00), p < 0.001]. Similarly, there were significant improvements in IDWG [2670.00 (1670.00-4300.00) vs. 1986.00 (1099.00-3998.00), p < 0.001] and FMD % [7.26 (4.55-8.56) vs. 9.56 (6.55-12.05), p < 0.001]. Serum MDA levels (p < 0.001) were significantly decreased; serum SOD (p < 0.001) and GPx (p < 0.001) activities were significantly increased after low sodium HD compared to standard sodium HD.

conclusionOur data seem to suggest a potential role of 137 mEq/L sodium dialysate for improving hemodynamic status, endothelial function and reducing oxidative stress than 140 mEq/L sodium dialysate in maintenance HD patients.

Indexed as

Kidney Failure, ChronicRenal DialysisSodiumAdultBlood PressureEndothelium, VascularFemaleHemodialysis SolutionsHumansMaleMiddle AgedMonitoring, PhysiologicOxidative StressStatistics as TopicHemodialysis SolutionsSodiumDialysate sodiumEndothelial dysfunctionHemodialysisOxidative stress

Identifiers

PMID27473155
OpenAlexW2497423975

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.