ArticleJournal of biomedical science2016
Vitamin D3/VDR resists diet-induced obesity by modulating UCP3 expression in muscles.
Article in Journal of biomedical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Vitamin D supplementation in individuals with type 1 diabetes mellitus (T1DM): a systematic review and meta-analysis focusing on pediatrics.Diabetology & metabolic syndrome · 2025Article
- The Role of Solute Carrier Family Transporters in Hepatic Steatosis and Hepatic Fibrosis.Journal of clinical and translational hepatology · 2025Review
- Type 1 Diabetes Autoimmunity: To What Extent Vitamin D is Beneficial.Biochemistry research international · 2025Review
- Elevated TyG index is associated with increased risk of vitamin D deficiency among elderly patients with type 2 diabetes.Scientific reports · 2024Article
- High-fat diet effects on contractile performance of isolated mouse soleus and extensor digitorum longus when supplemented with high dose vitamin D.Experimental physiology · 2024Article
- Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function.Nutrients · 2023Review
- Relationship between the weight-adjusted-waist index and kidney stone: a population-based study.World journal of urology · 2023Article
- Review
- A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice.Nutrition & metabolism · 2023Article
- Association between the Triglyceride-Glucose Index and Vitamin D Status in Type 2 Diabetes Mellitus.Nutrients · 2023Article
- Ketogenic Diet and Vitamin D Metabolism: A Review of Evidence.Metabolites · 2022Review
- Metabolic Advantage of 25(OH)DCells · 2022Article
- Review
- Differential Effects of 25-Hydroxyvitamin DCells · 2021Article
- Review
- Vitamin D Supplementation and Impact on Skeletal Muscle Function in Cell and Animal Models and an Aging Population: What Do We Know So Far?Nutrients · 2021Review
- Sex-Specific Effects of Vitamin D Status on the Metabolic Profile in Prediabetic Subjects.International journal of endocrinology · 2021Article
- Vitamin D ameliorates adipose browning in chronic kidney disease cachexia.Scientific reports · 2020Article
- Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis-associated cachexia.Journal of cachexia, sarcopenia and muscle · 2020Article
- The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes.Frontiers in bioengineering and biotechnology · 2020Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of vitamin D3 (VD3) on obesity has been reported in the past. Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.
methodsEight-week-old C57BL/6 J male mice were fed a normal- or high-fat diet for 9 weeks and were treated with a gavage of vehicle (corn oil) or cholecalciferol (50 μg/kg, daily). Body weight, white adipose tissue weight, blood lipid and glucose levels were measured. In addition, we investigated the expression of 1,25(OH)2D3 (calcitriol)/VDR-regulated genes involved in energy and lipid metabolism, such as of uncoupling protein 3 (UCP3), by using qRT-PCR in the liver, adipose tissue, skeletal muscle and C2C12, L6, and H-EMC-SS cells. We also measured UCP3 promoter transcription in the same cell lines using a Dual Luciferase Assay. Furthermore, we analyzed the binding site consensus sequences of VDR on the UCP3 promoter.
resultsMice consuming a high-fat diet treated with cholecalciferol had lower body weight and adipose tissue weight and higher expression of UCP3 compared to the other treatment groups. Changes in the expression of genes correlated with calcitriol/VDR. Luciferase activity was dose-dependently associated with calcitriol/VDR levels. We confirmed the functional VDR binding site consensus sequences at -2200, -1561, -634, and +314 bp in the UCP3 promoter region.
conclusionWe suggest that VD3/VDR inhibits weight gain by activating UCP3 in the muscles.
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Registered trials
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