Evidence map›Paper›PMID 27473009›Full record

ArticlePediatric surgery international2016

Anaplastic histology Wilms' tumors registered to the Japan Wilms' Tumor Study Group are less aggressive than that in the National Wilms' Tumor Study 5.

Takaharu Oue, Tsugumichi Koshinaga, Tetsuya Takimoto, Hajime Okita, Yukichi Tanaka, Miwako Nozaki, Masayuki Haruta, Yasuhiko Kaneko, Masahiro Fukuzawa, Renal Tumor Committee of the Japanese Children’s Cancer Group

Abstract read
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Article in Pediatric surgery international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. The genetic changes of Wilms tumour.Nature reviews. Nephrology · 2019
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Takaharu OueDepartment of Pediatric Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 63-8501, Japan. ta-oue@hyo-med.ac.jp.
Tsugumichi KoshinagaDepartment of Pediatric Surgery, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Tetsuya TakimotoDivision of Registration and Research for Childhood Cancer, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Hajime OkitaDepartment of Pathology, Keio University, Shinjyuku-ku, Tokyo, Japan.
Yukichi TanakaDepartment of Pathology, Kanagawa Children's Medical Center, Yokohama, Kanagawa, Japan.
Miwako NozakiDepartment of Radiology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan.
Masayuki HarutaResearch Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan.
Yasuhiko KanekoResearch Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan.
Masahiro FukuzawaOsaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan.
Renal Tumor Committee of the Japanese Children’s Cancer Group
Saitama Cancer Center · JPDokkyo Medical University Saitama Medical Center · JPHyogo Medical University · JPKanagawa Children's Medical Center · JPKeio University · JPNational Center For Child Health and Development · JPNihon University · JPOsaka Medical Center for Cancer and Cardiovascular Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the clinical features and treatment results of anaplastic histology (AH) Wilms' tumor (WT) patients registered in the Japan Wilms' Tumor Study (JWiTS) group to elucidate the clinical characteristics of AH in the Japanese population. PATIENTS AND

methodsOf 344 WT patients who were enrolled in JWiTS between 1995 and 2013, 17 had AH. Treatment using the JWiTS protocols was similar to the fifth National Wilms' Tumor Study 5 (NWTS-5) protocols. Clinical characteristics and mutation status of TP53 gene were evaluated and compared with those in NWST-5 study.

resultsAH incidences in JWiTS were 4.9 %, lower than that in NWTS-5. Seven tumors had focal AH and 10 had diffuse AH. Clinical stages of AH patients were stage I in seven, stage II in three, stage III in five, stage IV in one and unknown in one. Four-year event-free survival and overall survival rates were 90.9 and 86.7 %, respectively. Two patients with diffuse AH and none with focal AH had TP53 mutation.

conclusionJapanese patients presented with higher incidence, earlier stages and may have better outcomes than American patients, indicating a possible biological heterogeneity of AH WT. Further analysis is necessary to elucidate the different characteristic of AH WT between Japanese and American populations.

Indexed as

AnaplasiaChild, PreschoolFemaleHumansInfantJapanKidneyKidney NeoplasmsMaleNeoplasm StagingRegistriesTumor Suppressor Protein p53Wilms TumorTP53 protein, humanTumor Suppressor Protein p53AnaplasticJWiTSNWTSTP53 mutationWilms’ tumor

Identifiers

PMID27473009
OpenAlexW2488967570

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.