ArticleMolecular brain2016
Potentiation of synaptic transmission in Rat anterior cingulate cortex by chronic itch.
Article in Molecular brain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Supraspinal Circuit Mechanisms Underlying Itch Processing.CNS neuroscience & therapeutics · 2026Review
- Processing of pain and itch information by modality-specific neurons within the anterior cingulate cortex in mice.Nature communications · 2025Article
- Cell Type-Specific Modulation of Acute Itch Processing in the Anterior Cingulate Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A thalamic nucleus reuniens-lateral septum-lateral hypothalamus circuit for comorbid anxiety-like behaviors in chronic itch.Science advances · 2024Article
- Enhanced long-term potentiation in the anterior cingulate cortex of tree shrew.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- An Anterior Cingulate Cortex-to-Midbrain Projection Controls Chronic Itch in Mice.Neuroscience bulletin · 2023Article
- Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex.Biomedicines · 2022Review
- Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of CaFrontiers in molecular neuroscience · 2021Article
- The Role of Gut Microbiota in Chronic Itch-Evoked Novel Object Recognition-Related Cognitive Dysfunction in Mice.Frontiers in medicine · 2021Article
- The lateral habenula is critically involved in histamine-induced itch sensation.Molecular brain · 2020Article
- Central circuit mechanisms of itch.Nature communications · 2020Review
- Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex.Molecular brain · 2020Article
- Altered expression of itch‑related mediators in the lower cervical spinal cord in mouse models of two types of chronic itch.International journal of molecular medicine · 2019Article
- The vicious cycle of itch and anxiety.Neuroscience and biobehavioral reviews · 2018Review
- Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors.Molecular brain · 2017Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Itch and pain share similar mechanisms. It has been well documented that the anterior cingulate cortex (ACC) is important for pain-related perception. ACC has also been approved to be a potential pruritus-associated brain region. However, the mechanism of sensitization in pruriceptive neurons in the ACC is not clear. In current study, a chronic itch model was established by diphenylcyclopropenone (DCP) application. We found that both the frequency and amplitude of miniature excitatory postsynaptic currents in the ACC were enhanced after the formation of chronic itch. The paired-pulse ratio in ACC neurons recorded from the DCP group were smaller than those recorded in control group at the 50-ms interval. We also observe a significant increase in the AMPA/NMDA ratio in the DCP group. Moreover, an increased inward rectification of AMPARs in ACC pyramidal neurons was observed in the DCP group. Interestingly, the calculated ratio of silent synapses was significantly reduced in the DCP group compared with controls. Taken together, we conclude that a potentiation of synaptic transmission in the ACC can be induced by chronic itch, and unsilencing silent synapses, which probably involved recruitment of AMPARS, contributed to the potentiation of postsynaptic transmission.
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