ArticleJournal of Alzheimer's disease : JAD2016
The Identification of Aluminum in Human Brain Tissue Using Lumogallion and Fluorescence Microscopy.
Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Macrophage-MediatedACS applied materials & interfaces · 2026Article
- Comparative Cytokine and Histology Studies on HPV and Other Viral Vaccinations: No Pathogenicity of HPV Vaccine Adjuvants.Cancer science · 2025Article
- Airborne Aluminum as an Underestimated Source of Human Exposure: Quantification of Aluminum in 24 Human Tissue Types Reveals High Aluminum Concentrations in Lung and Hilar Lymph Node Tissues.Environmental science & technology · 2024Article
- Microglial Activation in Metal Neurotoxicity: Impact in Neurodegenerative Diseases.BioMed research international · 2023Review
- Hematologic evaluation of peripheral blood in Sprague Dawley rats by chronic exposure to aluminum chloride (AlCl3).Environmental analysis, health and toxicology · 2022Article
- Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats.Metabolites · 2022Article
- A Significant Fluorescence Turn-On Probe for the Recognition of AlMolecules (Basel, Switzerland) · 2022Article
- Aluminium co-localises with Biondi ring tangles in Parkinson's disease and epilepsy.Scientific reports · 2022Observational
- Article
- Aluminum Enters Mammalian Cells and Destabilizes Chromosome Structure and Number.International journal of molecular sciences · 2021Article
- Detection of aluminium hydroxide-induced granulomas in sheep by computed tomography: A feasible approach for small ruminant lentiviruses diagnosis and research.Veterinary medicine and science · 2021Article
- Aluminum and Tau in Neurofibrillary Tangles in Familial Alzheimer's Disease.Journal of Alzheimer's disease reports · 2021Article
- Probabilistic Risk Analysis to Assess Dietary Exposure to Aluminum in the Taiwanese Population.International journal of environmental research and public health · 2021Article
- Replication of Small Ruminant Lentiviruses in Aluminum Hydroxide-Induced Granulomas in Sheep: a Potential New Factor for Viral Dissemination.Journal of virology · 2020Article
- Article
- Unequivocal imaging of aluminium in human cells and tissues by an improved method using morin.Histochemistry and cell biology · 2019Article
- Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford.International journal of environmental research and public health · 2019Article
- Intracellular Aluminium in Inflammatory and Glial Cells in Cerebral Amyloid Angiopathy: A Case Report.International journal of environmental research and public health · 2019Article
- Egg White Hydrolysate as a functional food ingredient to prevent cognitive dysfunction in rats following long-term exposure to aluminum.Scientific reports · 2019Article
- Aluminium in Brain Tissue in Multiple Sclerosis.International journal of environmental research and public health · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aluminum in human brain tissue is implicated in the etiologies of neurodegenerative diseases including Alzheimer's disease. While methods for the accurate and precise measurement of aluminum in human brain tissue are widely acknowledged, the same cannot be said for the visualization of aluminum. Herein we have used transversely-heated graphite furnace atomic absorption spectrometry to measure aluminum in the brain of a donor with Alzheimer's disease, and we have developed and validated fluorescence microscopy and the fluor lumogallion to show the presence of aluminum in the same tissue. Aluminum is observed as characteristic orange fluorescence that is neither reproduced by other metals nor explained by autofluorescence. This new and relatively simple method to visualize aluminum in human brain tissue should enable more rigorous testing of the aluminum hypothesis of Alzheimer's disease (and other neurological conditions) in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.