Evidence map›Paper›PMID 27472872›Full record

ArticleJournal of Alzheimer's disease : JAD2016

A Depressive Endophenotype for Predicting Cognitive Decline among Mexican American Adults and Elders.

Leigh A Johnson, Adriana Gamboa, Raul Vintimilla, Melissa Edwards, James Hall, Brent Weiser, Menaka Yadav, Tony Dickensheets, Sid E O'Bryant

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Precision medicine for Alzheimer's disease in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leigh A JohnsonInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
Adriana GamboaInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
Raul VintimillaInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
Melissa EdwardsInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
James HallInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
Brent WeiserTexas College of Osteopathic Medicine, Fort Worth, TX, USA.
Menaka YadavTexas College of Osteopathic Medicine, Fort Worth, TX, USA.
Tony DickensheetsInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
Sid E O'BryantInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.

Funding

A Blood-Based Screening Tool for Alzheimer's DiseaseR01AG039389 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E · 2012 to 2013
$608k
NIA NIH HHS R01 AG039389NIMHD NIH HHS L60 MD001849
6 · The paper itself

Abstract

backgroundLate life depression is a prodromal feature and a risk factor for Alzheimer's disease (AD) and mild cognitive impairment (MCI). We identified five items in the Geriatric Depression scale (DepE) that are important as a risk for MCI and AD: memory problems, feeling blue, crying, feeling worthless, and trouble concentrating.

objectiveOur goal was to examine the relationship between DepE and cognition in a cohort of Mexican Americans.

methodsData from 317 Mexican Americans from the HABLE study were analyzed. DepE scores were dichotomized into two groups: endorsement of 1 item or less, and endorsement of 2 or more items. Cognition was assessed via neuropsychological tests, and diagnosis was based on consensus review. We utilized linear regression to examine the association between DepE and cognitive performance, and logistic regression to examine the utility of DepE in predicting MCI. To examine the impact of DepE on memory over 12 months, we performed ANOVA analysis.

resultsElevated DepE scores were associated with poorer performance on various measures of memory and cognition, but not executive or visual spatial skills. Over 12 months, we found a decline in immediate memory among women but not men. Those with high scores were 4 times more likely to have MCI. ANOVA of total scores revealed differences between groups on immediate memory (p < 0.05) in women, with no significant differences on delay recall in either gender.

conclusionDepE can be utilized in Mexican Americans to identify those at risk of memory related cognitive decline.

Indexed as

AgedAged, 80 and overCognitionCognitive AgingCognitive DysfunctionDepressionEndophenotypesExecutive FunctionFemaleHumansLongitudinal StudiesMaleMemoryMexican AmericansMiddle AgedNeuropsychological TestsAlzheimer’s diseasecognitive declinedepressionendophenotypeMexican Americanmild cognitive impairment

Identifiers

PMID27472872
PMCPMC13270980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.