ArticleMedicine2016
Functional mitral regurgitation: predictor for atrial substrate remodeling and poor ablation outcome in paroxysmal atrial fibrillation.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- A prediction model based on functional mitral regurgitation for the recurrence of paroxysmal atrial fibrillation (PAF) after post-circular pulmonary vein radiofrequency ablation (CPVA).Echocardiography (Mount Kisco, N.Y.) · 2022Trial
- Preprocedural cardiac computed tomography assessment of left atrial posterior wall morphology predicts atrial tachyarrhythmia recurrence after cryoballoon pulmonary vein isolation.Heart rhythm O2 · 2026Article
- Predictors of Sinus Rhythm Maintenance After Catheter Ablation in Atrial Fibrillation Patients With Significant Atrial Functional Mitral Regurgitation.Circulation reports · 2025Article
- The Association Between Significant Mitral Regurgitation and Atrial Fibrillation Recurrence Post-Ablation.Journal of clinical medicine · 2025Article
- Clinical, Electrocardiographic and Echocardiographic Predictors of Atrial Fibrillation Recurrence After Pulmonary Vein Isolation.Journal of clinical medicine · 2025Review
- Unraveling the interplay: early-stage atrial functional mitral regurgitation and left atrial electrical substrate in atrial fibrillation patients.Frontiers in cardiovascular medicine · 2024Article
- The role and implications of left atrial fibrosis in surgical mitral valve repair as assessed by CMR: the ALIVE study design and rationale.Frontiers in cardiovascular medicine · 2023Article
- Clinical significance of substrate characteristics and ablation outcomes in patients with atrial fibrillation and significant functional mitral regurgitation.Frontiers in cardiovascular medicine · 2023Article
- Association of Mitral Regurgitation with Postoperative Atrial Fibrillation in Critically Ill Noncardiac Surgery Patients: A Prospective Cohort Study.International journal of general medicine · 2023Article
- Mitral valve surgery for atrial functional mitral regurgitation: predicting recurrent mitral regurgitation and mid-term outcome.General thoracic and cardiovascular surgery · 2022Article
- Echocardiographic diagnosis of atrial cardiomyopathy allows outcome prediction following pulmonary vein isolation.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- Functional Mitral Regurgitation in Patients with Preserved Ejection Fraction Qualified for Pulmonary Vein Isolation: A Negative Prognostic Factor for Catheter Ablation Efficacy.Medicina (Kaunas, Lithuania) · 2021Article
- Association between functional mitral regurgitation and recurrence of paroxysmal atrial fibrillation following catheter ablation: a prospective cohort study.The Journal of international medical research · 2021Article
- Echocardiographic predictors of atrial fibrillation recurrence after catheter ablation: A literature review.Cardiology journal · 2020Review
- Long-term outcomes of radiofrequency catheter ablation for atrial fibrillation in rheumatic heart disease patients with mild mitral stenosis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2019Article
- High Brain Natriuretic Peptide Level Predicts The Prevalence Of Low-Voltage Areas And Poor Rhythm Outcome In Patients Undergoing Atrial Fibrillation Ablation.Journal of atrial fibrillationArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional mitral regurgitation (FMR) is not uncommon in atrial fibrillation (AF) patients. We sought to investigate the association between FMR and atrial substrate remodeling as well as the ablation outcome in paroxysmal AF (PAF) patients.We retrospectively analyzed a prospectively enrolled cohort of 132 patients (age 55.1 ± 9.6 years, 75.8% male) with symptomatic PAF who underwent initial ablation in our institute. Functional mitral regurgitation was defined as regurgitation jet area to left atrium (LA) area ratio ≥ 0.1 without any primary valvular disease. Voltage mapping of LA was performed under sinus rhythm. Low voltage zones (LVZs) were semi-quantitatively estimated and presented as low voltage index. Follow-up for AF recurrence ≥ 12 months was performed.In total, 40 patients (29.6%) were detected with FMR, who were older than the non-FMR patients (P = 0.007) and had larger LA diameters (P = 0.02). Left atrium LVZs were observed in 64.9% of patients with FMR versus 22.1% patients without FMR (P < 0.001). Functional mitral regurgitation independently predicted the presence of LVZs (OR 7.286; 95% CI 3.023-17.562; P < 0.001). During a mean follow-up of 22.9 ± 6.5 months, 38 patients (28.8%) experienced AF recurrence. The recurrence rate was 60.0% and 19.5% in FMR and non-FMR cohort, respectively (log rank P < 0.001). Multivariate analysis showed that FMR was an independent predictor for AF recurrence (HR 2.291; 95% CI 1.062-4.942; P = 0.03).Functional mitral regurgitation was strongly associated with atrial substrate remodeling. Furthermore, patients with FMR have substantial risk for AF recurrence post ablation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.