ArticleMedicine2016
Impact of hepatic function on serum procalcitonin for the diagnosis of bacterial infections in patients with chronic liver disease: A retrospective analysis of 324 cases.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Procalcitonin and presepsin for detecting bacterial infection and spontaneous bacterial peritonitis in cirrhosis: A systematic review and meta-analysis.World journal of gastroenterology · 2025Pooled it
- Prognostic Value of Inflammatory Markers in Septic Critically Ill Patients with Chronic Liver Disease: A Retrospective Analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Prognostic value of neutrophil-to-lymphocyte ratio in end-stage liver disease: A meta-analysis.World journal of hepatology · 2024Article
- Article
- Dietary supplementation of low levels of unprocessed Mucuna pruriens utilis seed meal induces mild antinutritional entero-physio-metabolic perturbations without compromising performance and meat quality in finisher broilers.Tropical animal health and production · 2023Article
- Liver cirrhosis and immune dysfunction.International immunology · 2022Review
- Procalcitonin in early allograft dysfunction after orthotopic liver transplantation: a retrospective single centre study.BMC gastroenterology · 2022Article
- Clinico-bacterial and prognostic factors in patients with suspected blood stream infection and elevated serum procalcitonin levels.Nagoya journal of medical science · 2022Article
- Postoperative serum myoglobin as a predictor of early allograft dysfunction after liver transplantation.Frontiers in surgery · 2022Article
- Plasma procalcitonin may be an early predictor of liver injury in acetaminophen poisoning: A prospective cohort study.United European gastroenterology journal · 2021Observational
- Diagnostic Accuracy of Procalcitonin for Bacterial Infection in Liver Failure: A Meta-Analysis.Bioinorganic chemistry and applications · 2021Article
- Development of a novel score for the diagnosis of bacterial infection in patients with acute-on-chronic liver failure.World journal of gastroenterology · 2020Article
- Procalcitonin: A promising tool or just another overhyped test?International journal of medical sciences · 2020Review
- Procalcitonin and Liver Disease: A Literature Review.Journal of clinical and translational hepatology · 2019Review
- [Diagnosis and treatment of bacterial infection in patients with end-stage liver disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018Article
- Article
- Bacterial infections in patients with liver cirrhosis: clinical characteristics and the role of C-reactive protein.Annals of gastroenterologyArticle
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although procalcitonin (PCT) is a valid marker for early diagnosis of bacterial infections, it is unclear whether its accuracy in predicting bacterial infections is affected by impaired liver function. This study aimed to assess the impact of compromised liver function on the diagnostic value of PCT.This retrospective study was conducted between January 2013 and May 2015. A total of 324 patients with chronic liver disease were enrolled. Routine laboratory measurements and PCT were performed. Patients were divided into 3 groups according to clinical diagnosis: chronic hepatitis (group 1), decompensated cirrhosis (group 2), and acute-on-chronic liver failure/chronic liver failure (group 3). The correlation between PCT and liver function was analyzed. The area under the receiver operating characteristic (AUCROC) curve of PCT was analyzed according to infection status and liver function.PCT was more accurate than white blood cell count (P < 0.001) and percentage of neutrophils (P < 0.001) in detecting bacterial infections in patients with impaired liver function. In patients without infection, PCT had a moderate positive correlation with serum total bilirubin (TBIL) (r = 0.592), and a weak correlation with model for end-stage liver disease score (r = 0.483) and international normalized ratio (r = 0.389). The AUCROC and optimum thresholds of PCT and for predicting bacterial infections at different levels of TBIL were 0.907 (95% CI 0.828-0.958) and 0.38 ng/mL, respectively, for TBIL <5 mg/dL, 0.927 (95% CI 0.844-0.974) and 0.54 ng/mL (5 mg/dL ≤TBIL<10 mg/dL), 0.914 (95% CI 0.820-0.968) and 0.61 ng/mL (10 mg/dL ≤TBIL<20 mg/dL), 0.906 (95% CI 0.826-0.958) and 0.94 ng/mL (TBIL ≥20 mg/dL), respectively.This study demonstrated that PCT was a valuable marker of bacterial infection in patients with chronic liver diseases. TBIL affected PCT threshold, so different cut-offs should be used according to different TBIL values.
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