ArticleNMR in biomedicine2016
Towards longitudinal mapping of extracellular pH in gliomas.
Article in NMR in biomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Monocyte-hitchhiking system for the targeted delivery of paclitaxel-loaded PLGA nanoparticles to glioblastoma in mice.Journal of nanobiotechnology · 2026Article
- Overcoming Immune Exclusion in a Murine Model of Cirrhotic Hepatocellular Carcinoma via Cryoablation: Insights from Molecular Extracellular pH Imaging.Research square · 2025Article
- High-resolution quantitative mapping of extracellular pH by ratiometric MRI with iron chelates in a tumor mouse model.La Radiologia medica · 2025Article
- Minimally invasive measurement of carotid artery and brain temperature in the mouse.Magnetic resonance in medicine · 2025Article
- A targeted fluorescent nanosensor for ratiometric pH sensing at the cell surface.Scientific reports · 2024Article
- Transmembrane pH gradient imaging in rodent glioma models.NMR in biomedicine · 2024Article
- Article
- Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery.Bioactive materials · 2022Article
- Extracellular pH Mapping as Therapeutic Readout of Drug Delivery in Glioblastoma.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI.Cancers · 2021Article
- Imaging Extracellular Acidification and Immune Activation in Cancer.Current opinion in biomedical engineering · 2021Article
- Imaging the transmembrane and transendothelial sodium gradients in gliomas.Scientific reports · 2021Article
- Imaging Hallmarks of the Tumor Microenvironment in Glioblastoma Progression.Frontiers in oncology · 2021Article
- Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy.Translational oncology · 2020Article
- Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner.Magnetic resonance in medicine · 2020Article
- Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- High-resolution label-free 3D mapping of extracellular pH of single living cells.Nature communications · 2019Article
- Phosphocreatine Levels in the Left Thalamus Decline during Wakefulness and Increase after a Nap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH.Scientific reports · 2017Article
- Brain Tumor Diagnostics and Therapeutics with Superparamagnetic Ferrite Nanoparticles.Contrast media & molecular imaging · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Biosensor imaging of redundant deviation in shifts (BIRDS), an ultrafast chemical shift imaging technique, requires infusion of paramagnetic probes such as 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis methylene phosphonate (DOTP(8-) ) complexed with thulium (Tm(3+) ) ion (i.e. TmDOTP(5-) ), where the pH-sensitive resonances of hyperfine-shifted non-exchangeable protons contained within the paramagnetic probe are detected. While imaging extracellular pH (pHe ) with BIRDS meets an important cancer research need by mapping the intratumoral-peritumoral pHe gradient, the surgical intervention used to raise the probe's plasma concentration limits longitudinal scans on the same subject. Here we describe using probenecid (i.e. an organic anion transporter inhibitor) to temporarily restrict renal clearance of TmDOTP(5-) , thereby facilitating molecular imaging by BIRDS without surgical intervention. Co-infusion of probenecid with TmDOTP(5-) increased the probe's distribution into various organs, including the brain, compared with infusing TmDOTP(5-) alone. In vivo BIRDS data using the probenecid-TmDOTP(5-) co-infusion method in rats bearing RG2, 9 L, and U87 brain tumors showed intratumoral-peritumoral pHe gradients that were unaffected by the probe dose. This co-infusion method can be used for pHe mapping with BIRDS in preclinical models for tumor characterization and therapeutic monitoring, given the possibility of repeated scans with BIRDS (e.g. over days and even weeks) in the same subject. The longitudinal pHe readout by the probenecid-TmDOTP(5-) co-infusion method for BIRDS adds translational value in tumor assessment and treatment. Copyright © 2016 John Wiley & Sons, Ltd.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.