Evidence map›Paper›PMID 27472352›Full record

ArticleInternational journal of environmental research and public health2016

Hemoglobin Status and Externalizing Behavioral Problems in Children.

Jianhua Su, Naixue Cui, Guoping Zhou, Yuexian Ai, Guiju Sun, Sophie R Zhao, Jianghong Liu

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jianhua SuDepartment of Neurology, The Jintan Hospital Affiliated to Jiangsu University, 16 Nanmen Street, Jintan, Changzhou 213200, China. sujianhua961211@sina.com.
Naixue CuiSchools of Nursing and Medicine, University of Pennsylvania, 418 Curie Blvd., Room 426, Claire M. Fagin Hall, Philadelphia, PA 19104, USA. naixuec@nursing.upenn.edu.
Guoping ZhouDepartment of Neurology, The Jintan Hospital Affiliated to Jiangsu University, 16 Nanmen Street, Jintan, Changzhou 213200, China. zhou.guoping@hotmail.com.
Yuexian AiDepartment of Neurology, The Jintan Hospital Affiliated to Jiangsu University, 16 Nanmen Street, Jintan, Changzhou 213200, China. ayx5096@163.com.
Guiju SunDepartment of Nutrition and Food Hygiene, School of Public Health, Southeast University, Room #508, 87, DingJiaqiao, Nanjing 210096, China. guiju.sun@gmail.com.
Sophie R ZhaoSchools of Nursing and Medicine, University of Pennsylvania, 418 Curie Blvd., Room 426, Claire M. Fagin Hall, Philadelphia, PA 19104, USA. sophie.r.zhao@hotmail.com.
Jianghong LiuSchools of Nursing and Medicine, University of Pennsylvania, 418 Curie Blvd., Room 426, Claire M. Fagin Hall, Philadelphia, PA 19104, USA. jhliu@nursing.upenn.edu.
Jiangsu University · CNUniversity of Pennsylvania · USSoutheast University · CN

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Lead exposure, externalizing behavior, and neurobiological mediating factorsR01ES018858 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG · 2010 to 2014
$1.7M
Mechanisms that mediate the link between lead exposure and child behavior problemK02ES019878 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG · 2011 to 2015
$656k
Environmental Toxicity, Malnutrition, and Children's Externalizing BehaviorK01ES015877 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIU, JIANGHONG · 2007 to 2010
$605k
NIEHS NIH HHS K01 ES015877NIEHS NIH HHS K02 ES019878NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES018858
6 · The paper itself

Abstract

backgroundStill considered one of the most prevalent nutritional problems in the world, anemia has been shown in many studies to have deleterious effects on neurobehavioral development. While most research efforts have focused on investigating the effects of anemia on social and emotional development of infants by using a cross-sectional design, research is still needed to investigate whether early childhood anemia, beyond infantile years, is linked with behavioral problems.

objectiveThis study assessed whether (1) hemoglobin (Hb) levels in early childhood are associated with externalizing behavior; and (2) this relationship is confounded by social adversity.

methodsHemoglobin levels were taken from children (N = 98) of the China Jintan Cohort Study at age 4 years, and externalizing behaviors (attention and aggression) were assessed with the Child Behavior Checklist (ASEBA-CBCL) at age 6 years (mean age 5.77 ± 0.39 years old).

resultsCompared with other children in the sample, children with relatively lower Hb levels at age 4 had more behavioral problems in both attention and aggression at age 6, independent of social adversity. For boys, this association was significant for attention problems, which did not interact with social adversity. For girls, the association was significant for aggression, which interacted with social adversity. While girls on average exhibited higher social adversity than boys, the main effect of Hb was only significant in girls with low social adversity.

conclusionsThese results indicate that there is an inverse association between hemoglobin levels and later behavioral problems. Findings of this study suggest that regular monitoring of children's hemoglobin levels and appropriate intervention may help with early identification of behavioral problems.

Indexed as

Problem BehaviorAggressionAnemiaAttentionChildChild, PreschoolChinaCohort StudiesCross-Sectional StudiesFemaleHemoglobinsHumansMaleHemoglobinsaggressionattention problemsChinese childrenexternalizing behaviorhemoglobin

Identifiers

PMID27472352
PMCPMC4997444
OpenAlexW2476382455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.