Broadening Horizons: New Antibodies Against Influenza.

Katherine J L Jackson, Scott D Boyd

Abstract readComment

In one paragraph

Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Seasonal and pandemic influenza: 100 years of progress, still much to learn.Mucosal immunology · 2020
Review
Advances in Vaccines to Prevent Viral Respiratory Illnesses in Children.Paediatric drugs · 2017
Review
Understanding the human antibody repertoire.mAbs
Review
Current strategies for detecting functional convergence across B-cell receptor repertoires.mAbs
Article

4 · The record

Corrections and comments

Comment on
Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.2016
Comment on
Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.2016

5 · Who and what money

Authors and funding

2 authors.

Katherine J L JacksonDepartment of Pathology, Stanford University, CA 94305, USA.

Scott D BoydDepartment of Pathology, Stanford University, CA 94305, USA. Electronic address: sboyd1@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seasonal influenza vaccine formulation efforts struggle to keep up with viral antigenic variation. Two studies now report engineered or naturally occurring human antibodies targeting the influenza hemagglutinin (HA) stem, with exceptional neutralizing breadth (Joyce et al., 2016; Kallewaard et al., 2016). Antibodies with similar structural features are elicited in multiple subjects, suggesting that modified vaccine regimens could provide broad protection.

Indexed as

Antibodies, NeutralizingAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza, HumanInfluenza VaccinesAntibodies, NeutralizingAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusInfluenza Vaccines

Identifiers

PMID27471961

DOI10.1016/j.cell.2016.07.023

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.