Evidence map›Paper›PMID 27471864›Full record

Trial reportBlood cancer journal2016

Randomized phase III trial of consolidation therapy with bortezomib-lenalidomide-Dexamethasone (VRd) vs bortezomib-dexamethasone (Vd) for patients with multiple myeloma who have completed a dexamethasone based induction regimen.

S J Jacobus, S V Rajkumar, M Weiss, A K Stewart, E A Stadtmauer, N S Callander, L M Dreosti, M Q Lacy, R Fonseca

Open access · goldAbstract readClinical Trial, Phase IIILetterMulticenter Study
In one paragraph

Trial report in Blood cancer journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

S J JacobusDana Farber Cancer Institute - ECOG-ACRIN Biostatistics Center, Boston, MA, USA.
S V RajkumarMayo Clinic, Rochester, MN, USA.
M WeissThedaCare, Appleton, WI, USA.
A K StewartMayo Clinic in Arizona, Scottsdale, AZ, South Africa.
E A StadtmauerUniversity of Pennsylvania, Philadelphia, PA, USA.
N S CallanderUniversity of Wisconsin, Madison, WI, USA.
L M DreostiUniversity of Pretoria, Pretoria, South Africa.
M Q LacyMayo Clinic, Rochester, MN, USA.
R FonsecaMayo Clinic in Arizona, Scottsdale, AZ, South Africa.
Mayo Clinic in Arizona · USDana-Farber Cancer Institute · USThedaCare · USUniversity of Pennsylvania · USUniversity of Pretoria · ZAUniversity of Wisconsin–Madison · US

Funding

ECOG-ACRIN NCORP Research Base - TMISTUG1CA189828 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$199.7M
Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$167.6M
ECOG OPERATIONS OFFICE (IBCSG)U10CA021115 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI COMIS, ROBERT L · 1985 to 2013
$132.6M
Statistics CoreU10CA180794 · NCI · DANA-FARBER CANCER INST · PI PAUL J CATALANO, CONSTANTINE A. GATSONIS · 2014 to 2026
$111.2M
ECOG Statistical Office Data Management GrantU10CA066636 · NCI · FRONTIER SCI &TECHNOLOGY RSCH FDN, INC · PI GRAY, ROBERT J · 1994 to 2013
$39.5M
PROVIDE STATISTICAL SERVICESU10CA023318 · NCI · DANA-FARBER CANCER INSTITUTE · PI GRAY, ROBERT J · 1985 to 2013
$33.4M
Wisconsin NCI Community Oncology Research Program (WiNCORP)UG1CA189956 · NCI · MARSHFIELD CLINIC RESEARCH FOUNDATION · PI ADEDAYO A ONITILO, Kurt Oettel · 2014 to 2026
$32.3M
Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Rafael Fonseca · 2015 to 2026
$25.5M
MARSHFIELD COMMUNITY CLINICAL ONCOLOGY PROGRAMU10CA035412 · NCI · MARSHFIELD CLINIC RESEARCH FOUNDATION · PI REDING, DOUGLAS J · 1985 to 2014
$11.1M
EASTERN COOPERATIVE ONCOLOGY GROUP--WISCONSIN STUDIESU10CA021076 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KAHL, BRAD · 1985 to 2013
$8.2M
Naional Cancer Institute, Naitonal Clinical Trials Network U10 Lead Academic SiteU10CA180790 · NCI · MAYO CLINIC ROCHESTER · PI ALBERTS, STEVEN R, BOUGHEY, JUDY CAROLINE · 2014 to 2018
$6.6M
ONCOLOGYU10CA015488 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LUGER, SELINA M · 1985 to 2013
$5.6M
NCI NIH HHS P50 CA186781NCI NIH HHS U10 CA013650NCI NIH HHS U10 CA015488NCI NIH HHS U10 CA021076NCI NIH HHS U10 CA021115NCI NIH HHS U10 CA023318NCI NIH HHS U10 CA035412NCI NIH HHS U10 CA066636NCI NIH HHS U10 CA180790NCI NIH HHS U10 CA180794NCI NIH HHS U10 CA180799NCI NIH HHS U10 CA180820NCI NIH HHS UG1 CA189828NCI NIH HHS UG1 CA189956
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Consolidation ChemotherapyInduction ChemotherapyAgedAntineoplastic Combined Chemotherapy ProtocolsBortezomibDexamethasoneFemaleHumansLenalidomideMaleMiddle AgedMultiple MyelomaSalvage TherapySurvival AnalysisThalidomideTreatment OutcomeBortezomibDexamethasoneLenalidomideThalidomide

Identifiers

PMID27471864
PMCPMC5030380
OpenAlexW2482033962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.