ArticleJournal of renal injury prevention2016
Tempol effects on diabetic nephropathy in male rats.
Article in Journal of renal injury prevention, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Environmental Nephrotoxicity Across the Life Course: Oxidative Stress Mechanisms and Opportunities for Early Intervention.Antioxidants (Basel, Switzerland) · 2025Review
- Administration of Trichinella spiralis Antigens Alleviated Diabetic Nephropathy in Diabetic Mice.Acta parasitologica · 2025Article
- Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized albumin as a biomarker.BMC nephrology · 2024Article
- Tempol treatment normalizes membrane expression of epithelial transport proteins in the kidney of salt-loaded hypertensive diabetic db/db mice.American journal of translational research · 2023Article
- In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-β1/SMAD3/NOX4 Cue.Molecules (Basel, Switzerland) · 2021Article
- The Effect of Chilgoza Pine Nut (Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Effect of Rosmarinic Acid and Sinapic Acid on Oxidative Stress Parameters in the Cardiac Tissue and Serum of Type 2 Diabetic Female Rats.Antioxidants (Basel, Switzerland) · 2019Article
- Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells.Scientific reports · 2018Article
- Tempol effect on epithelial-mesenchymal transition induced by hyperglycemia.Journal of nephropathology · 2017Article
- Evaluation of selenium on kidney function following ischemic injury in rats; protective effects and antioxidant activity.Journal of renal injury prevention · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDiabetic nephropathy (DN) is the most common cause of the chronic kidney disease in the world. Oxidative stress on the other hand has a major and well known role in its pathophysiology.
objectivesThe aim of the study is to figure out if tempol, a synthetic antioxidant agent, modifies DN and to determine its relevance to changes of serum oxidative biomarkers. MATERIALS AND
methodsTwenty-seven male rats were equally divided in to 4 groups (7 rats for each group). Group I (control or C), group II (diabetic or D), groups III (Tempol) which were given tempol (100 mg/kg/day) by gavages for 28 days and group IV (D&T) which includes diabetic rats that also received same dose of tempol. After treatment, blood samples were isolated. Enzymatic scavengers including catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities, lipid peroxidation (LPO), total antioxidant capacity (TAC) and total thiol molecules (TTM) were measured. Blood urea nitrogen (BUN), creatinine (Cr) an albumin/Cr ratio were evaluated as well. Statistical differences were assessed with one-way analysis of variance (ANOVA) by SPSS followed by Tukey t test.
resultsOxidative stress biomarkers modified and Alb/Cr ratio increased in diabetic group (II), however, they were altered to normal in group IV (D&T) compared with diabetic group (D).
conclusionTempol can modify oxidative stress biomarkers and presumably nephropathy in diabetic rats.
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Registered trials
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