Evidence map›Paper›PMID 27471687›Full record

ReviewImmunoTargets and therapy2013

Update on the challenges and recent advances in cancer immunotherapy.

Gianfranco Baronzio, Gurdev Parmar, Irina Zh Shubina, Valter Cassutti, Sergio Giuli, Marco Ballerini, Mikhail Kiselevsky

Abstract readReview
In one paragraph

Review in ImmunoTargets and therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Novel insights into the role of aptamers in the fight against cancer.Journal of cancer research and clinical oncology · 2019
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gianfranco BaronzioCentro Medico Demetra: Hyperthermia and Immunity Center, Terni, Italy.
Gurdev ParmarIntegrated Health Clinic, Fort Langley, British Columbia, Canada.
Irina Zh ShubinaBlokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
Valter CassuttiCentro Medico Demetra: Hyperthermia and Immunity Center, Terni, Italy.
Sergio GiuliCentro Medico Demetra: Hyperthermia and Immunity Center, Terni, Italy.
Marco BalleriniCentro Medico Demetra: Hyperthermia and Immunity Center, Terni, Italy.
Mikhail KiselevskyBlokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This overview provides an analysis of some of the immunotherapies currently in use and under investigation, with a special focus on the tumor microenvironment, which we believe is a major factor responsible for the general failure of immunotherapy to date. It is our expectation that combining immunotherapy with methods of altering the tumor microenvironment and targeting regulatory T cells and myeloid cells will yield favorable results.

Indexed as

CTLA-4exosomesimmunosuppressionmyeloid-derived suppressor cellsPD-1Tregstumor immunitytumor microenvironment

Identifiers

PMID27471687
PMCPMC4928368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.