ArticleGut pathogens2016
Genome sequence of OXA-23 producing Acinetobacter baumannii IHIT7853, a carbapenem-resistant strain from a cat belonging to international clone IC1.
Article in Gut pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 26 citations in OpenAlex.
- The population structure ofApplied and environmental microbiology · 2026Article
- Genomics unveils country-to-country transmission between animal hospitals of a multidrug-resistant and sequence type 2Microbial genomics · 2024Article
- Multiple host colonization and differential expansion of multidrug-resistant ST25-Acinetobacter baumannii clades.Scientific reports · 2023Article
- Antimicrobial Susceptibility Profiles ofVeterinary sciences · 2023Article
- Analyses of Extended-Spectrum-β-Lactamase, Metallo-β-Lactamase, and AmpC-β-Lactamase Producing Enterobacteriaceae from the Dairy Value Chain in India.Antibiotics (Basel, Switzerland) · 2023Article
- Carbapenem resistance in critically important human pathogens isolated from companion animals: a systematic literature review.Osong public health and research perspectives · 2022Article
- Genomic Analysis ofAntibiotics (Basel, Switzerland) · 2022Article
- Molecular Characterization of GermanPathogens (Basel, Switzerland) · 2021Article
- Endemicity of OXA-23 and OXA-72 in clinical isolates of Acinetobacter baumannii from three neighbouring countries in Southeast Europe.Journal of applied genetics · 2021Article
- Review
- Article
- Acinetobacter baumannii - a neglected pathogen in veterinary and environmental health in Germany.Veterinary research communications · 2019Review
- Seasonal Occurrence and Carbapenem Susceptibility of BovineFrontiers in microbiology · 2019Article
- OXA-72-Mediated Carbapenem Resistance in Sequence Type 1 Multidrug (Colistin)-Resistant Acinetobacter baumannii Associated with Urinary Tract Infection in a Dog from Serbia.Antimicrobial agents and chemotherapy · 2018Article
- Hospitalized Pets as a Source of Carbapenem-Resistance.Frontiers in microbiology · 2018Article
- Prevalence and Emergence of Extended-Spectrum Cephalosporin-, Carbapenem- and Colistin-Resistant Gram Negative Bacteria of Animal Origin in the Mediterranean Basin.Frontiers in microbiology · 2018Review
- Carbapenem-resistance and pathogenicity of bovine Acinetobacter indicus-like isolates.PloS one · 2017Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultidrug resistance in Acinetobacter baumannii has dramatically increased in recent years worldwide. Thus, last-line antibiotics like carbapenems are increasingly being used which in turn further augments selection pressure for resistant strains. Resistance to carbapenems in A. baumannii is frequently mediated by carbapenemases, particularly OXA-23 and OXA-58. Carbapenemase-producing bacteria are mainly described in human patients and the intestinal tract represents a common source for such pathogens. In this study, we sequenced and analyzed the genome of A. baumannii IHIT7853, a carbapenem-resistant, OXA-23 producing strain isolated from cystitis in a cat in 2000 in Germany.
resultsPhylogenetic analysis revealed that IHIT7853 belonged to the globally distributed international clone IC1 and MLST type ST1/ST231 (Pasteur/Oxford MLST scheme). A phylogenetic tree based on the maximum common genome of 18 A. baumannii isolates placed IHIT7853 close to human clinical isolates, such as the multidrug-resistant (MDR) outbreak strain AYE that was isolated from a patient with pneumonia and cystitis in 2001 in France. The OXA-23 plasmid sequence could be determined as 53,995 bp in size, possessing resistance genes strA and strB in addition to bla OXA-23.
conclusionsThe analysis of the genome of IHIT7853 reveals that companion animals carry MDR A. baumannii that resemble relevant clonal lineages involved in severe infections in humans. As urinary tract infections are often caused by bacteria that reside in the intestinal tract, future studies should unveil, if the animal gut serves as a source for MDR A. baumannii.
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