ArticleFrontiers in microbiology2016
Growth of Streptococcus mutans in Biofilms Alters Peptide Signaling at the Sub-population Level.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- LytF contributes to pilus extrusion during natural competence inJournal of bacteriology · 2026Article
- Epigenomics identifies three sources of DNA methylation inbioRxiv : the preprint server for biology · 2026Article
- Effects of pH on the Properties of Membrane Vesicles Including Glucosyltransferase inMicroorganisms · 2021Article
- The transcription regulator BrsR serves as a network hub of natural competence protein-protein interactions inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Spatial Correlations and Distribution of Competence Gene Expression in Biofilms ofFrontiers in microbiology · 2020Article
- Expanding the Vocabulary of Peptide Signals inFrontiers in cellular and infection microbiology · 2019Review
- Threshold regulation and stochasticity from the MecA/ClpCP proteolytic system in Streptococcus mutans competence.Molecular microbiology · 2018Article
- Competence inhibition by the XrpA peptide encoded within the comX gene of Streptococcus mutans.Molecular microbiology · 2018Article
- Genome-Wide Screens Reveal New Gene Products That Influence Genetic Competence in Streptococcus mutans.Journal of bacteriology · 2018Article
- The tRNA biology · 2018Article
- Intercellular Communication via theJournal of bacteriology · 2017Article
- Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence.Nature communications · 2017Article
- Raffinose Induces Biofilm Formation by Streptococcus mutans in Low Concentrations of Sucrose by Increasing Production of Extracellular DNA and Fructan.Applied and environmental microbiology · 2017Article
- Modification of theMicrobial genomics · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Streptococcus mutans activates multiple cellular processes in response to the formation of a complex between comX-inducing peptide (XIP) and the ComR transcriptional regulator. Bulk phase and microfluidic experiments previously revealed that ComR-dependent activation of comX is altered by pH and by carbohydrate source. Biofilm formation is a major factor in bacterial survival and virulence in the oral cavity. Here, we sought to determine the response of S. mutans biofilm cells to XIP during different stages of biofilm maturation. Using flow cytometry and confocal microscopy, we showed that exogenous addition of XIP to early biofilms resulted in robust comX activation. However, as the biofilms matured, increasing amounts of XIP were required to activate comX expression. Single-cell analysis demonstrated that the entire population was responding to XIP with activation of comX in early biofilms, but only a sub-population was responding in mature biofilms. The sub-population response of mature biofilms was retained when the cells were dispersed and then treated with XIP. The proportion and intensity of the bi-modal response of mature biofilm cells was altered in mutants lacking the Type II toxins MazF and RelE, or in a strain lacking the (p)ppGpp synthase/hydrolase RelA. Thus, competence signaling is markedly altered in cells growing in mature biofilms, and pathways that control cell death and growth/survival decisions modulate activation of comX expression in these sessile populations.
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