ArticleFrontiers in behavioral neuroscience2016
Association between Exposure to the Chinese Famine in Different Stages of Early Life and Decline in Cognitive Functioning in Adulthood.
Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Do prenatal factors shape the risk for dementia?: A systematic review of the epidemiological evidence for the prenatal origins of dementia.Social psychiatry and psychiatric epidemiology · 2025Pooled it
- Dietary intakes and biomarker patterns of folate, vitamin BClinical epigenetics · 2019Trial
- Patterns of cognitive function in middle-aged and elderly Chinese adults-findings from the EMCOA study.Alzheimer's research & therapy · 2018Trial
- Association between fetal exposure to the Chinese famine and cognitive decline in adulthood: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Vulnerability of the Hippocampus to Insults: Links to Blood-Brain Barrier Dysfunction.International journal of molecular sciences · 2024Review
- Cerebral Small Vessel Disease: Early-Life Antecedents and Long-Term Implications for the Brain, Aging, Stroke, and Dementia.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Sound-localization-related activation and functional connectivity of dorsal auditory pathway in relation to demographic, cognitive, and behavioral characteristics in age-related hearing loss.Frontiers in neuroscience · 2024Article
- 27-hydroxycholesterol causes cognitive deficits by disturbing Th17/Treg balance and the related immune responses in mild cognitive impairment patients and C57BL/6J mice.Journal of neuroinflammation · 2023Article
- Adversity specificity and life period exposure on cognitive aging.Scientific reports · 2023Article
- Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age.Nutrients · 2023Article
- Spectral quantitative and semi-quantitative EEG provide complementary information on the life-long effects of early childhood malnutrition on cognitive decline.Frontiers in neuroscience · 2023Article
- The Long-Term Effect of Famine Exposure on Cognitive Performance: Evidence from the 1959-1961 Chinese Famine.International journal of environmental research and public health · 2022Article
- Prenatal exposure to the Dutch famine is associated with more self-perceived cognitive problems at 72 years of age.BMC geriatrics · 2022Article
- Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study.Frontiers in human neuroscience · 2022Article
- Association of Parental Famine Exposure With Offspring Depression and Cognition Function.Frontiers in psychiatry · 2022Article
- The Effect and Mechanism of Cholesterol and Vitamin BFrontiers in aging neuroscience · 2021Article
- Combined Effect of Famine Exposure and Obesity Parameters on Hypertension in the Midaged and Older Adult: A Population-Based Cross-Sectional Study.BioMed research international · 2021Article
- Consequences of early life exposure to the 1983-1985 Ethiopian Great Famine on cognitive function in adults: a historical cohort study.BMJ open · 2020Article
- Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study.Molecular neurodegeneration · 2019Article
- Influence of collateral circulation on cerebral blood flow and frontal lobe cognitive function in patients with severe internal carotid artery stenosis.BMC neurology · 2019Article
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Authors and funding
8 authors.
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Abstract
objectiveTo investigate whether exposure to the Chinese Famine in different life stages of early life is associated with cognitive functioning decline in adulthood.
methodsWe recruited 1366 adults born between 1950 and 1964 and divided them into fetal-exposed, early childhood-exposed (1-3 years old during the famine), mid childhood-exposed (4-6 years old during the famine), late childhood-exposed (7-9 years old during the famine), and non-exposed groups. A selection of cognitive tests was administered to assess their cognitive performance. Association between malnutrition in different famine exposure periods and adult cognitive performance was estimated by multivariate logistic and multiple linear regression analyses.
resultsThere were significant differences in cognitive performance between subjects exposed to famine during different life stages. For the general cognitive tests, fetal-exposed period was associated with decreased scores of the Mini-Mental State Examination (MMSE), and late childhood-exposed with decreased scores of the Montreal Cognitive Assessment (MoCA). We also found exposure to famine during mid and late childhood was associated with worse performance on the Stroop color and word test.
conclusionFamine exposure in utero and during childhood is associated with overall and specific cognitive decline, affecting selective attention and response inhibition particularly.
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