ArticleDrug design, development and therapy2016
Simvastatin attenuates radiation-induced salivary gland dysfunction in mice.
Article in Drug design, development and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Prevalence and Risk Factors of Oral Lesions in a Portuguese Subpopulation: A Retrospective Study.Journal of clinical medicine · 2025Article
- Synthetic and Natural Radioprotective Agents: Recent Status and their Underlying Mechanism of Action.Current pharmaceutical biotechnology · 2025Review
- Will Nigella sativa oil protect parotid glands of rats against cranium gamma irradiation? Histological and immunohistochemical evaluation.BMC complementary medicine and therapies · 2024Article
- Crosstalk between Oxidative Stress and Inflammation Induced by Ionizing Radiation in Healthy and Cancerous Cells.Current medicinal chemistry · 2024Review
- Statins in Cancer Prevention and Therapy.Cancers · 2023Review
- Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review.Cureus · 2023Review
- A preclinical model to investigate normal tissue damage following fractionated radiotherapy to the head and neck.Journal of radiation research · 2023Article
- Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments.Life sciences in space research · 2022Article
- Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry.Antioxidants (Basel, Switzerland) · 2022Review
- Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice.Scientific reports · 2022Article
- Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage.Radiation and environmental biophysics · 2022Article
- Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Review
- Smad7 attenuates TGF-β-mediated aging-related hypofunction of submandibular glands.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Commonalities Between COVID-19 and Radiation Injury.Radiation research · 2021Review
- Experimental Animal Model Systems for Understanding Salivary Secretory Disorders.International journal of molecular sciences · 2020Review
- The effects of statins on dental and oral health: a review of preclinical and clinical studies.Journal of translational medicine · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveStatins are widely used lipid-lowering drugs, which have pleiotropic effects, such as anti-inflammation, and vascular protection. In our study, we investigated the radioprotective potential of simvastatin (SIM) in a murine model of radiation-induced salivary gland dysfunction.
designNinety-six Institute of Cancer Research mice were randomly divided into four groups: solvent + sham irradiation (IR) (Group I), SIM + sham IR (Group II), IR + solvent (Group III), and IR + SIM (Group IV). SIM (10 mg/kg body weight, three times per week) was administered intraperitoneally 1 week prior to IR through to the end of the experiment. Saliva and submandibular gland tissues were obtained for biochemical, morphological (hematoxylin and eosin staining and Masson's trichrome), and Western blot analysis at 8 hours, 24 hours, and 4 weeks after head and neck IR.
resultsIR caused a significant reduction of salivary secretion and amylase activity but elevation of malondialdehyde. SIM remitted the reduction of saliva secretion and restored salivary amylase activity. The protective benefits of SIM may be attributed to scavenging malondialdehyde, remitting collagen deposition, and reducing and delaying the elevation of transforming growth factor β1 expression induced by radiation.
conclusionSIM may be clinically useful to alleviate side effects of radiotherapy on salivary gland.
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