ArticleThe European respiratory journal2016
High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study.
Article in The European respiratory journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 2 of them syntheses that pooled it.
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108 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.
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- Prevalence, Risk Factors, and Outcomes of Adult Interstitial Lung Abnormalities: A Systematic Review and Meta-Analysis.American journal of respiratory and critical care medicine · 2023Pooled it
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- Changes in the Quantitative Computed Tomography Values in Drug-associated Interstitial Lung Disease Caused by Non-anticancer Drugs.Internal medicine (Tokyo, Japan) · 2026Article
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- Incidental pulmonary findings on CT in daily practice: the nodule and the interstitial lung abnormalities - what's old, what's new.La Radiologia medica · 2026Review
- Development of imaging protocol and radiomics-based nomogram for assessing lesion reversibility in connective tissue disease-associated interstitial lung disease.BMC medical imaging · 2026Article
- Cryobiopsy at the dawn of fibrosis: unlocking early diagnosis and therapeutic windows.Frontiers in medicine · 2026Review
- Extent of alveolar collapse in expiratory CT as a prognostic marker in idiopathic pulmonary fibrosis.PloS one · 2026Article
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- Antiphospholipid antibodies and subclinical interstitial lung disease in the MESA cohort.Respiratory research · 2025Observational
- Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis.NPJ Regenerative medicine · 2025Article
- Associations of High Attenuation Area-Related Proteomic Biomarkers with Fibrotic or Subpleural Interstitial Lung Abnormalities.American journal of respiratory and critical care medicine · 2025Article
- Integrating CT radiomics and clinical features using machine learning to predict post-COVID pulmonary fibrosis.Respiratory research · 2025Article
- Air pollution and alveolar health.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- The potential of semi-quantitative and quantitative methods in predicting progression in rheumatoid arthritis-associated interstitial lung disease.Clinical rheumatology · 2025Observational
- Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis.bioRxiv : the preprint server for biology · 2025Article
- A Comprehensive Review of Interstitial Lung Abnormalities.Respirology (Carlton, Vic.) · 2025Review
- Associations of albuminuria with interstitial lung abnormalities in older community-dwelling adults confounded by age.ERJ open research · 2025Article
48 more citing papers are in PubMed but not listed here.
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26 authors at 14 institutions in 1 country.
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Abstract
Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lung injury, inflammation and extracellular matrix remodelling in community-dwelling adults sampled without regard to respiratory symptoms or smoking.We measured high attenuation areas (HAA; percentage of lung voxels between -600 and -250 Hounsfield Units) on cardiac CT scans of adults enrolled in the Multi-Ethnic Study of Atherosclerosis.HAA was associated with higher serum matrix metalloproteinase-7 (mean adjusted difference 6.3% per HAA doubling, 95% CI 1.3-11.5), higher interleukin-6 (mean adjusted difference 8.8%, 95% CI 4.8-13.0), lower forced vital capacity (FVC) (mean adjusted difference -82 mL, 95% CI -119--44), lower 6-min walk distance (mean adjusted difference -40 m, 95% CI -1--80), higher odds of interstitial lung abnormalities at 9.5 years (adjusted OR 1.95, 95% CI 1.43-2.65), and higher all cause-mortality rate over 12.2 years (HR 1.58, 95% CI 1.39-1.79).High attenuation areas are associated with biomarkers of inflammation and extracellular matrix remodelling, reduced lung function, interstitial lung abnormalities, and a higher risk of death among community-dwelling adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.