Evidence map›Paper›PMID 27471058›Full record

ReviewFamily process2016

Family-Focused Therapy for Bipolar Disorder: Reflections on 30 Years of Research.

David J Miklowitz, Bowen Chung

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Family process, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 63 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 5 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03913013 phase1 / phase2completednot on this mapstarted 2018, after this paper: background citation

Technology-Enhanced Family-Focused Treatment for Adolescents at High Risk for Mood Disorders

TypeinterventionalSponsorUniversity of California, Los AngelesRan2018 to 2021Enrolled65ConditionsMood Disorders, Bipolar Disorder, Major DepressionArmsFamily-Focused Treatment with MCC App
NCT04338152 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2021 to 2026Enrolled220ConditionsPsychotic Disorders, Prodromal Symptoms, Prodromal Schizophrenia, PsychosisArmsFamily Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC)
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 5 syntheses or guidelines pooled it, 230 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Trial
  7. Trial
  8. Trial
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  12. Family communication with teens at clinical high-risk for psychosis or bipolar disorder.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2018
    Trial
  13. Trial
  14. Article
  15. Review
  16. Review
  17. Addressing the unmet needs of bipolar disorder in Australia and beyond.The Australian and New Zealand journal of psychiatry · 2025
    Article
  18. Article
  19. Comorbid Cannabis Use and Mood Disorders Among Adolescents.Focus (American Psychiatric Publishing) · 2025
    Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David J MiklowitzDepartment of Psychiatry and Behavioral Sciences, UCLA School of Medicine, Los Angeles, CA. dmiklowitz@mednet.ucla.edu.
Bowen ChungDepartment of Psychiatry and Behavioral Sciences, UCLA School of Medicine, Los Angeles, CA.
University of California, Los Angeles · US

Funding

1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Family-Focused Treatment for Bipolar AdolescentsR01MH073871 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2006 to 2010
$1.7M
Family-Focused Therapy for Youth with Early-Onset Bipolar or Psychotic Disorders R33MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2014 to 2016
$853k
Family-Focused Treatment for Youth with Early-Onset Bipolar or Psychotic DisorderR21MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2013
$439k
NIMH NIH HHS R01 MH073871NIMH NIH HHS R01 MH093676NIMH NIH HHS R21 MH097007NIMH NIH HHS R33 MH097007
6 · The paper itself

Abstract

Family-focused therapy (FFT) is an evidence-based intervention for adults and children with bipolar disorder (BD) and their caregivers, usually given in conjunction with pharmacotherapy after an illness episode. The treatment consists of conjoint sessions of psychoeducation regarding bipolar illness, communication enhancement training, and problem-solving skills training. This paper summarizes over 30 years of research on FFT and family processes in BD. Across eight randomized controlled trials with adults and adolescents with BD, FFT and mood-stabilizing medications have been found to hasten recovery from mood episodes, reduce recurrences, and reduce levels of symptom severity compared to briefer forms of psychoeducation and medications over 1-2 years. Several studies indicate that the effects of FFT on symptom improvement are greater among patients with high-expressed emotion relatives. New research focuses on FFT as an early intervention for youth at risk for BD, neuroimaging as a means of evaluating treatment mechanisms, and progress in implementing FFT in community mental health settings.

Indexed as

AdolescentAdultBipolar DisorderCaregiversChildCombined Modality TherapyFamilyFamily TherapyFemaleHumansMalePsychotropic DrugsTreatment OutcomeYoung AdultPsychotropic DrugsBipolar Disorderemoción expresadaExpressed EmotionFamily-Focused TherapyFamily InteractionFFTFunctional Magnetic Resonance Imaginginteracciones familiarespsicosisPsychosisresonancia magnética funcionalterapia centrada en la familiatrastorno bipolar功能性核磁共振家庭互动表达情感躁郁症重性精神病

Identifiers

PMID27471058
PMCPMC5922774
OpenAlexW2482154376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.