ArticleDevelopmental biology2017
Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Arabidopsis as a model for translational research.The Plant cell · 2025Review
- Novel laser model of optic nerve transection provides valuable insights about the dynamics of optic nerve regeneration.Scientific reports · 2024Article
- Novel laser model of optic nerve transection provides valuable insights about the dynamics of optic nerve regeneration.Research square · 2024Article
- Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium.Molecular neurodegeneration · 2023Review
- Dual leucine zipper kinase is necessary for retinal ganglion cell axonal regeneration inPNAS nexus · 2023Article
- Profiling Dynamic Changes in DNA Accessibility During Axon Regeneration After Optic Nerve Crush in Adult Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Surgical Methods in Postmetamorphic Xenopus laevis: Optic Nerve Crush Injury Model.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Translating Ribosome Affinity Purification (TRAP) and Bioinformatic RNA-Seq Analysis in Post-metamorphic Xenopus laevis.Methods in molecular biology (Clifton, N.J.) · 2023Article
- LCM-Seq for Retinal Cell Layer-Specific Responses During Optic Nerve Regeneration.Methods in molecular biology (Clifton, N.J.) · 2023Article
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- The basic science of optic nerve regeneration.Annals of translational medicine · 2021Review
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- Article
- CYP1B1 gene: Implications in glaucoma and cancer.Journal of Cancer · 2020Review
- Morpholinos Do Not Elicit an Innate Immune Response during Early Xenopus Embryogenesis.Developmental cell · 2019Review
- Timing of neuronal plasticity in development and aging.Wiley interdisciplinary reviews. Developmental biology · 2018Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Unlike adult mammals, adult frogs regrow their optic nerve following a crush injury, making Xenopus laevis a compelling model for studying the molecular mechanisms that underlie neuronal regeneration. Using Translational Ribosome Affinity Purification (TRAP), a method to isolate ribosome-associated mRNAs from a target cell population, we have generated a transcriptional profile by RNA-Seq for retinal ganglion cells (RGC) during the period of recovery following an optic nerve injury. Based on bioinformatic analysis using the Xenopus laevis 9.1 genome assembly, our results reveal a profound shift in the composition of ribosome-associated mRNAs during the early stages of RGC regeneration. As factors involved in cell signaling are rapidly down-regulated, those involved in protein biosynthesis are up-regulated alongside key initiators of axon development. Using the new genome assembly, we were also able to analyze gene expression profiles of homeologous gene pairs arising from a whole-genome duplication in the Xenopus lineage. Here we see evidence of divergence in regulatory control among a significant proportion of pairs. Our data should provide a valuable resource for identifying genes involved in the regeneration process to target for future functional studies, in both naturally regenerative and non-regenerative vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.