Evidence map›Paper›PMID 27470992›Full record

ArticleStroke2016

Association of Major Depressive Episodes With Stroke Risk in a Prospective Study of 0.5 Million Chinese Adults.

Jie Sun, Hongxia Ma, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Hongbing Shen, Zhengming Chen and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  5. China stroke surveillance report 2021.Military Medical Research · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jie SunFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.).
Hongxia MaFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.).
Canqing YuFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.).
Jun LvFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.).
Yu GuoFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.).
Zheng BianFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.).
Ling YangFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.).
Yiping ChenFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.).
Hongbing ShenFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.).
Zhengming ChenFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.).
Zhibin HuFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.). zhibin_hu@njmu.edu.cn lmlee@vip.163.com.
Liming LiFrom the Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, China (J.S., H.M., H.S., Z.H.); Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (C.Y., J.L., L.L.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); and Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (L.Y., Y.C., Z.C.). zhibin_hu@njmu.edu.cn lmlee@vip.163.com.
China Kadoorie Biobank Collaborative Group
Nanjing Medical University · CNPeking University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Medical Research Council MC_U137686851Medical Research Council MC_UU_12026/2Wellcome Trust 088158Wellcome Trust 104085
6 · The paper itself

Abstract

background and purposeAlthough the relationship between depression and stroke risk has been investigated, findings in previous reports were conflicting. The aim of this study was to prospectively examine the effect of major depressive episodes (MDE) on stroke incidence and further assess the potential dose-response relationship between number of depression symptoms and subsequent stroke risk in Chinese population.

methodsA total of 199 294 men and 288 083 women aged 30 to 79 years without a history of stroke, heart disease, and cancer in the China Kadoorie Biobank cohort were followed from 2004 to 2013. A World Health Organization Composite International Diagnostic Interview-Short Form was used to access MDE according to Diagnostic and Statistical Manual of Mental Disorders-IV criteria. Stroke events were ascertained through death certificates, medical records, and health insurance data.

resultsPast year MDE was marginally associated with a 15% increased risk of stroke (adjusted hazard ratio, 1.15; 95% confidence interval, 0.99-1.33) in the fully adjusted model, and the association was steeper and statistically significant in individuals aged <50 years, smokers, drinkers, those with higher education degree, body mass index <24.0 kg/m(2), and no history of diabetes mellitus. Moreover, there was a positive dose-response relationship between the number of depression symptoms and increased stroke risk (Ptrend=0.011). In addition, smoking status significantly interacted with MDE on stroke onset (P for multiplicative interaction=0.025).

conclusionsFindings from this large prospective study suggest that the presence of MDE is a risk factor for stroke, especially in smokers.

Indexed as

AdultAgedAge FactorsChinaDepressionFemaleHumansIncidenceMajor Depressive DisorderMaleMiddle AgedRiskSex FactorsStrokedepressionprospective studystroke

Identifiers

PMID27470992
PMCPMC4998954
OpenAlexW2481110406

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.