ReviewCellular microbiology2016
Pondering neutrophil extracellular traps with healthy skepticism.
Review in Cellular microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 68 citations in OpenAlex.
- Sex-dependent effects of peptidylarginine deiminases on neutrophil function and long-term outcomes after spinal cord injury.Experimental neurology · 2025Article
- 2-chlorofatty acid modification of neutrophil proteins: identification, localization and role in NETosis.Cell communication and signaling : CCS · 2025Article
- Neutrophil extracellular traps are associated with airways inflammation and increased severity of lung disease in cystic fibrosis.ERJ open research · 2024Article
- The gasdermin family: emerging therapeutic targets in diseases.Signal transduction and targeted therapy · 2024Review
- Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice.Blood advances · 2023Article
- Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways.Immunological reviews · 2023Review
- New Insights into Neutrophil Extracellular Trap (NETs) Formation from Porcine Neutrophils in Response to Bacterial Infections.International journal of molecular sciences · 2022Article
- Low density neutrophils are increased in patients with Behçet's disease but do not explain differences in neutrophil function.Journal of inflammation (London, England) · 2022Article
- Unveiling Leukocyte Extracellular Traps in Inflammatory Responses of the Central Nervous System.Frontiers in immunology · 2022Review
- Neutrophil NET Formation with Microbial Stimuli Requires Late Stage NADPH Oxidase Activity.Antioxidants (Basel, Switzerland) · 2021Article
- New Insights on NETosis Induced byAntioxidants (Basel, Switzerland) · 2021Article
- Neutrophil Myeloperoxidase Derived Chlorolipid Production During Bacteria Exposure.Frontiers in immunology · 2021Article
- Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin.Scientific reports · 2020Article
- Neutrophil Extracellular Traps and Liver Disease.Seminars in liver disease · 2020Review
- Activated αeLife · 2020Article
- Cytonemes Versus Neutrophil Extracellular Traps in the Fight of Neutrophils with Microbes.International journal of molecular sciences · 2020Review
- Bioinspired nucleic acid structures for immune modulation.Biomaterials · 2019Review
- Neutrophil Extracellular Traps: Villains and Targets in Arterial, Venous, and Cancer-Associated ThrombosisArteriosclerosis, thrombosis, and vascular biology · 2019Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The authors engage in a dialogue that evaluates critically the state of the study of neutrophil extracellular traps (NETs), a phenomenon currently the object of considerable interest, with the goal of identifying those aspects that merit clarification in order to assign the process its proper place in our current understanding of cell biology. Since the seminal observations in the Zychlinsky laboratory that described the extrusion of filaments of nuclear DNA associated with histones and granule proteins from neutrophils stimulated in vitro, many investigators have examined the phenomenon of NET formation in numerous and diverse settings. However, an overview of work in this rapidly growing field prompts several fundamental questions about NETs, including their precise composition, the mechanisms by which they arise, their clinical relevance, and the interrelationship of those observed in vitro and in vivo. In this discussion, the authors challenge interpretation of data from some experimental settings and provide recommendations for specific studies that would address the concerns raised, improve understanding of the biological relevance of NETs, and strengthen the field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.