Evidence map›Paper›PMID 27470944›Full record

ArticleChemosphere2016

DPOAEs in infants developmentally exposed to PCBs show two differently time spaced exposure sensitive windows.

Vladimíra Koštiaková, Arturo Moleti, Soňa Wimmerová, Todd A Jusko, Ľubica Palkovičová Murínová, Renata Sisto, Denisa Richterová, Ján Kováč, Kamil Čonka, Henrieta Patayová and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Chemosphere, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Vladimíra KoštiakováSlovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
Arturo MoletiUniversity of Rome, Tor Vergata, Department of Physics, Rome, Italy.
Soňa WimmerováSlovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
Todd A JuskoDepartments of Public Health Sciences and Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Ľubica Palkovičová MurínováSlovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
Renata SistoINAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Monteporzio Catone, Italy.
Denisa RichterováSlovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
Ján KováčDepartment of Stomatology and Maxillofacial Surgery, Comenius University, Faculty of Medicine in Bratislava, Bratislava, Slovakia.
Kamil ČonkaSlovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
Henrieta PatayováSlovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
Juraj TihányiSlovak Medical University, Limbová 14, 83303, Bratislava, Slovakia.
Tomáš TrnovecSlovak Medical University, Limbová 14, 83303, Bratislava, Slovakia. Electronic address: tomas.trnovec@szu.sk.
Slovak Medical University · SKComenius University Bratislava · SKIstituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro · ITUniversity of Rochester · USUniversity of Rome Tor Vergata · IT

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
Early Childhood Development and PCB Exposures in Slovak*R01CA096525 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI HERTZ-PICCIOTTO, IRVA · 2001 to 2005
$2.3M
Women's Health and the Environment over the Entire Lifespan (WHEEL)K12ES019852 · NIEHS · UNIVERSITY OF ROCHESTER · PI CORY-SLECHTA, DEBORAH A · 2010 to 2014
$1.8M
PCBs and Otodevelopment in Eastern SlovakiaR03TW007152 · FIC · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA · 2006 to 2008
$100k
FIC NIH HHS R03 TW007152NCI NIH HHS R01 CA096525NIEHS NIH HHS K12 ES019852NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

The study aim was to identify the timing of sensitive windows for ototoxicity related to perinatal exposure to PCBs. A total of 351 and 214 children from a birth cohort in eastern Slovakia underwent otoacoustic testing at 45 and 72 months, respectively, and distortion product otoacoustic emissions (DPOAEs) at 11 frequencies were recorded. Cord and child 6-, 16-, 45-, and 72- month blood samples were analyzed for PCB 153 concentration. The PCB 153 concentration-time profiles were approximated with a system model to calculate area under the PCB*time curves (AUCs) for specific time intervals (3 and 6 months for 45 and 72 months data, respectively). DPOAE amplitudes were correlated (Spearman) with cord serum PCB and AUCs, markers of prenatal and postnatal exposure, respectively. Two exposure critical windows were identified in infants, the first related to prenatal and early postnatal and the second to postnatal exposure to PCBs. Our data have shown tonotopicity, sexual dimorphism, and asymmetry in ototoxicity of PCBs.

Indexed as

CochleaAudiometryChildCohort StudiesEnvironmental ExposureEnvironmental PollutantsFemaleFetal BloodHumansInfantMalePerceptual DistortionPolychlorinated BiphenylsPregnancyPrenatal Exposure Delayed EffectsSlovakia2,4,5,2',4',5'-hexachlorobiphenylEnvironmental PollutantsPolychlorinated BiphenylsCritical windows of exposureOtoacoustic emissionsOtotoxicityPolychlorinated biphenyls

Identifiers

PMID27470944
PMCPMC6042651
OpenAlexW2505798071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.