Evidence map›Paper›PMID 27470907›Full record

ArticleOral diseases2016

Distribution and factors associated with salivary secretory leukocyte protease inhibitor concentrations.

S Rahman, C M Pierce Campbell, B N Torres, M T O'Keefe, D J Ingles, L L Villa, R J Carvalho da Silva, R C Cintra, E Lazcano-Ponce, J Salmeron and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

S RahmanDepartment of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.
C M Pierce CampbellDepartment of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA. christine.piercecampbell@moffitt.org.
B N TorresDepartment of Biostatistics, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
M T O'KeefeDepartment of Performance Improvement, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
D J InglesVanderbilt Institute for Global Health, Nashville, TN, USA.
L L VillaDepartment of Radiology & Oncology, School of Medicine, University of São Paulo, São Paulo, Brazil.
R J Carvalho da SilvaCentro de Referencia e Treinamento em DST/Aids, São Paulo, Brazil.
R C CintraDepartment of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil.
E Lazcano-PonceInstituto Nacional de Salúd Publica, Cuernavaca, Mexico.
J SalmeronInstituto Nacional de Salúd Publica, Cuernavaca, Mexico.
M QuiterioInstituto Nacional de Salúd Publica, Cuernavaca, Mexico.
A R GiulianoDepartment of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Moffitt Cancer Center · USInstituto Nacional de Salud Pública · MXUniversidade de São Paulo · BRMexican Social Security Institute · MXVanderbilt Health · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Natural History of HPV Infection in Men: The HIM StudyR01CA098803 · NCI · H. LEE MOFFITT CANCER CTR &RES INST · PI GIULIANO, ANNA R. · 2004 to 2014
$18.2M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA098803
6 · The paper itself

Abstract

objectivesThis cross-sectional study examined the distribution and correlates of salivary secretory leukocyte protease inhibitor (SLPI) concentrations within a multinational cohort of men.

methodsExtracellular SLPI was measured in oral gargle cell supernatants of 378 men from three countries using an ELISA-based assay. Risk factor data were collected by a questionnaire. Factors associated with SLPI were assessed using linear and logistic regression for continuous and categorical SLPI, respectively.

resultsAmong men aged 18-73 years, the median SLPI concentration was 492.0 ng ml

conclusionsSecretory leukocyte protease inhibitor concentrations varied significantly by country and decreased with increasing age. The interaction between SLPI, modifiable factors, and oral infections that influence cancer risk warrants further investigation.

Indexed as

AdolescentAdultAgedAge FactorsCross-Sectional StudiesGingivitisHumansMaleMiddle AgedSalivaSecretory Leukocyte Peptidase InhibitorSexually Transmitted DiseasesYoung AdultSecretory Leukocyte Peptidase InhibitorHIM Studyimmune system proteinsalivasecretory leukocyte protease inhibitor

Identifiers

PMID27470907
PMCPMC5056814
OpenAlexW2504599526

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.