ArticleScientific reports2016
Identification of excitatory premotor interneurons which regulate local muscle contraction during Drosophila larval locomotion.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 48 citations in OpenAlex.
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- Regulation of excitation-contraction coupling at the Drosophila neuromuscular junction.The Journal of physiology · 2022Article
- TheFrontiers in neural circuits · 2021Review
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- Modelling the mechanics of exploration in larval Drosophila.PLoS computational biology · 2019Article
- Direction Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc.Current biology : CB · 2019Article
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- Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.BMC neuroscience · 2018Article
- The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia.Nature communications · 2018Article
- Data-driven analysis of motor activity implicates 5-HT2A neurons in backward locomotion of larval Drosophila.Scientific reports · 2018Article
- Neural circuits driving larval locomotion in Drosophila.Neural development · 2018Review
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- Neural Circuits Underlying Fly Larval Locomotion.Current pharmaceutical design · 2017Review
- Task switching is associated with temporal delays inBehavioral ecology : official journal of the International Society for Behavioral EcologyArticle
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We use Drosophila larval locomotion as a model to elucidate the working principles of motor circuits. Larval locomotion is generated by rhythmic and sequential contractions of body-wall muscles from the posterior to anterior segments, which in turn are regulated by motor neurons present in the corresponding neuromeres. Motor neurons are known to receive both excitatory and inhibitory inputs, combined action of which likely regulates patterned motor activity during locomotion. Although recent studies identified candidate inhibitory premotor interneurons, the identity of premotor interneurons that provide excitatory drive to motor neurons during locomotion remains unknown. In this study, we searched for and identified two putative excitatory premotor interneurons in this system, termed CLI1 and CLI2 (cholinergic lateral interneuron 1 and 2). These neurons were segmentally arrayed and activated sequentially from the posterior to anterior segments during peristalsis. Consistent with their being excitatory premotor interneurons, the CLIs formed GRASP- and ChAT-positive putative synapses with motoneurons and were active just prior to motoneuronal firing in each segment. Moreover, local activation of CLI1s induced contraction of muscles in the corresponding body segments. Taken together, our results suggest that the CLIs directly activate motoneurons sequentially along the segments during larval locomotion.
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