Evidence map›Paper›PMID 27470451›Full record

ArticleJournal of the American College of Cardiology2016

Underutilization of Coronary Artery Disease Testing Among Patients Hospitalized With New-Onset Heart Failure.

Darshan Doshi, Ori Ben-Yehuda, Machaon Bonafede, Noam Josephy, Dimitri Karmpaliotis, Manish A Parikh, Jeffrey W Moses, Gregg W Stone, Martin B Leon, Allan Schwartz and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American College of Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Review
  2. Observational
  3. Review
  4. Review
  5. Cardiometabolic Dysregulation and Heart Failure.Reviews in cardiovascular medicine · 2025
    Review
  6. Article
  7. Observational
  8. Article
  9. Review
  10. Article
  11. Article
  12. Observational
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Revascularisation for Ischaemic Cardiomyopathy.Interventional cardiology (London, England) · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Darshan DoshiDivision of Cardiology, Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York.
Ori Ben-YehudaDivision of Cardiology, Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York; Cardiovascular Research Foundation, New York, New York.
Machaon BonafedeTruven Health Analytics, Cambridge, Massachusetts.
Noam JosephyMassachusetts Institute of Technology, Cambridge, Massachusetts; Abiomed Inc., Danvers, Massachusetts.
Dimitri KarmpaliotisDivision of Cardiology, Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York; Cardiovascular Research Foundation, New York, New York.
Manish A ParikhDivision of Cardiology, Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York.
Jeffrey W MosesDivision of Cardiology, Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York; Cardiovascular Research Foundation, New York, New York.
Gregg W StoneDivision of Cardiology, Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York; Cardiovascular Research Foundation, New York, New York.
Martin B LeonDivision of Cardiology, Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York; Cardiovascular Research Foundation, New York, New York.
Allan SchwartzDivision of Cardiology, Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York.
Ajay J KirtaneDivision of Cardiology, Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York; Cardiovascular Research Foundation, New York, New York. Electronic address: akirtane@columbia.edu.

Funding

POSTDOCTORAL TRAINING IN CARDIOVASCULAR DISEASET32HL007854 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Marwah Abdalla, Michael Argenziano · 1996 to 2026
$14.7M
NHLBI NIH HHS T32 HL007854
6 · The paper itself

Abstract

backgroundAlthough ischemic coronary artery disease (CAD) is the most common etiology of heart failure (HF), the extent to which patients with new-onset HF actually undergo an ischemic work-up and/or revascularization is not well defined.

objectivesThis study sought to analyze the patterns of testing for ischemic CAD and revascularization in patients with new-onset HF.

methodsThis was a retrospective cohort study using Truven Health MarketScan Commercial and Medicare databases from 2010 to 2013. The occurrence of noninvasive and invasive ischemic CAD testing and revascularization procedures were examined among patients with new inpatient HF diagnoses during the index hospitalization and within 90 days of admission.

resultsAmong 67,161 patients identified with new-onset HF during an inpatient hospitalization, only 17.5% underwent testing for ischemic CAD during the index hospitalization, increasing to 27.4% at 90 days. Among patients with new-onset HF, only 2.1% underwent revascularization during the index hospitalization for HF; by 90 days, the revascularization rate had increased to 4.3%. Of the tests performed for ischemic CAD, stress testing (nuclear stress testing or stress echocardiography) was performed in 7.9% of new-onset HF patients during the index hospitalization (14.6% within 90 days), whereas coronary angiography was performed in 11.1% of patients during the index hospitalization (16.5% within 90 days). In adjusted analyses, HF patients carrying a baseline diagnosis of CAD had greater odds of noninvasive ischemic testing (odds ratio: 1.25; 95% confidence interval: 1.17 to 1.33; p < 0.0001), as well as invasive ischemic testing (odds ratio: 1.93; 95% confidence interval: 1.83 to 2.05; p < 0.0001), at the index hospitalization than those without baseline CAD.

conclusionsThe majority of patients hospitalized for new-onset HF did not receive testing for ischemic CAD either during hospitalization or within 90 days, which suggests significant underutilization of ischemic CAD assessment in new-onset HF patients.

Indexed as

AgedCoronary AngiographyCoronary Artery DiseaseEchocardiography, StressExercise TestFemaleFollow-Up StudiesHeart FailureHumansMaleRetrospective Studiesangiographyinvasiveischemic CADnoninvasiverevascularizationstress testing

Identifiers

PMID27470451
PMCPMC9135048

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.