Trial reportJournal of the American College of Cardiology2016
1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease: The PLATFORM Study.
Trial report in Journal of the American College of Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 173 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective LongitudinAl Trial of FFRct: Outcome and Resource IMpacts
The Effect of On-site CT-derived Fractional Flow Reserve on the Management Making for the Patients With Stable Chest Pain (TARGET Trial)
Who cites it
173 citing papers in PubMed, 3 syntheses or guidelines pooled it, 405 citations in OpenAlex.
- Pooled it
- Prognostic value of coronary computed tomography angiographic derived fractional flow reserve: a systematic review and meta-analysis.Heart (British Cardiac Society) · 2022Pooled it
- SCCT 2021 Expert Consensus Document on Coronary Computed Tomographic Angiography: A Report of the Society of Cardiovascular Computed Tomography.Journal of cardiovascular computed tomographyGuideline
- Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy.Journal of the American Heart Association · 2025Trial
- Combined prognostic value of AI-derived CT-FFR and high-risk plaque characteristics in patients with newly diagnosed chronic coronary syndrome: a prospective cohort study.Frontiers in cardiovascular medicine · 2025Trial
- Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial.European heart journal · 2021Trial
- Cost-effectiveness Analysis of Anatomic vs Functional Index Testing in Patients With Low-Risk Stable Chest Pain.JAMA network open · 2020Trial
- Integration of CTA in the Diagnostic Workup of New Onset Chest Pain in Clinical Practice.BioMed research international · 2019Trial
- Clinical Management Across CAD-RADS Categories in Patients with Intermediate CT-FFR.Journal of cardiovascular development and disease · 2026Article
- Beyond Angiography: Redefining The Gold Standard for Coronary Atherosclerosis.Current cardiology reports · 2026Review
- Clinical Applications of Artificial Intelligence in Cardiac CT: From Coronary CT Angiography to CT-Derived Fractional Flow Reserve and Myocardial Perfusion Imaging.Korean journal of radiology · 2026Review
- Optimizing coronary artery disease management: the role of CT-derived fractional flow reserve in predicting revascularization and guiding clinical decisions.BMC medical imaging · 2026Article
- Comparative assessment of non-invasive imaging methods for coronary artery disease: coronary computed tomography angiography, computed tomography-derived fractional flow reserve and instantaneous wave-free ratio computed tomography.The international journal of cardiovascular imaging · 2026Review
- Review
- The Contemporary Role of Intracoronary Physiological Assessment: Fractional Flow Reserve, Non-Hyperemic Pressure Ratios, Wireless Technologies, and Microcirculation.Journal of cardiovascular development and disease · 2026Review
- Clinical use of coronary computed tomography angiography-derived fractional flow reserve: expert consensus by an International Working Group.European radiology · 2026Article
- Artificial Intelligence-Driven Fractional Flow Reserve Assessment: Technical Foundations, Clinical Insights, and Future Directions.Medicina (Kaunas, Lithuania) · 2026Review
- Coronary Computed Tomography Angiography for the Diagnosis and Revascularization Guidance of Coronary Bifurcation Lesions: A Contemporary Review.Journal of clinical medicine · 2026Review
- Coronary CT Angiography in PCI Planning: Advances, Clinical Applications, and Challenges.Journal of cardiovascular development and disease · 2026Review
- From Plaque to Perfusion: A Narrative Review of Multimodality Imaging in Acute Coronary Syndromes.Journal of clinical medicine · 2026Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
24 authors at 15 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary computed tomographic angiography (CTA) plus estimation of fractional flow reserve using CTA (FFRCT) safely and effectively guides initial care over 90 days in patients with stable chest pain. Longer-term outcomes are unknown.
objectivesThe study sought to determine the 1-year clinical, economic, and quality-of-life (QOL) outcomes of using FFRCT instead of usual care.
methodsConsecutive patients with stable, new onset chest pain were managed by either usual testing (n = 287) or CTA (n = 297) with selective FFRCT (submitted in 201, analyzed in 177); 581 of 584 (99.5%) completed 1-year follow-up. Endpoints were adjudicated major adverse cardiac events (MACE) (death, myocardial infarction, unplanned revascularization), total medical costs, and QOL.
resultsPatients averaged 61 years of age with a mean 49% pre-test probability of coronary artery disease. At 1 year, MACE events were infrequent, with 2 in each arm of the planned invasive group and 1 in the planned noninvasive cohort (usual care strategy). In the planned invasive stratum, mean costs were 33% lower with CTA and selective FFRCT ($8,127 vs. $12,145 usual care; p < 0.0001); in the planned noninvasive stratum, mean costs did not differ when using an FFRCT cost weight of zero ($3,049 FFRCT vs. $2,579; p = 0.82), but were higher when using an FFRCT cost weight equal to CTA. QOL scores improved overall at 1 year (p < 0.001), with similar improvements in both groups, apart from the 5-item EuroQOL scale scores in the noninvasive stratum (mean change of 0.12 for FFRCT vs. 0.07 for usual care; p = 0.02).
conclusionsIn patients with stable chest pain and planned invasive coronary angiography, care guided by CTA and selective FFRCT was associated with equivalent clinical outcomes and QOL, and lower costs, compared with usual care over 1-year follow-up. (The PLATFORM Study: Prospective LongitudinAl Trial of FFRct: Outcome and Resource IMpacts [PLATFORM]; NCT01943903).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.