SynthesisEuropean journal of nuclear medicine and molecular imaging2016
A systematic review of lessons learned from PET molecular imaging research in atypical parkinsonism.
Synthesis in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Regional dopaminergic dysfunction patterns discriminate Parkinson's disease from multiple system atrophy parkinsonian subtype.Clinical parkinsonism & related disorders · 2026Article
- Pathomechanisms of neuropsychiatric disturbances in atypical parkinsonian disorders: a current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- The Spectrum of Cognitive Impairment in Atypical Parkinsonism Syndromes: A Comprehensive Review of Current Understanding and Research.Diseases (Basel, Switzerland) · 2025Review
- Characteristics of cerebral glucose metabolism in patients with cognitive impairment in multiple system atrophy.Frontiers in aging neuroscience · 2025Article
- Atypical Parkinsonian Syndromes: Structural, Functional, and Molecular Imaging Features.AJNR. American journal of neuroradiology · 2024Review
- Asymmetry in Atypical Parkinsonian Syndromes-A Review.Journal of clinical medicine · 2024Review
- Multidimensional biomarkers for multiple system atrophy: an update and future directions.Translational neurodegeneration · 2023Review
- Differences in Striatal Metabolism in [Diagnostics (Basel, Switzerland) · 2022Article
- Molecular Imaging of the GABAergic System in Parkinson's Disease and Atypical Parkinsonisms.Current neurology and neuroscience reports · 2022Review
- Diffusion Magnetic Resonance Imaging Microstructural Abnormalities in Multiple System Atrophy: A Comprehensive Review.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool.Frontiers in aging neuroscience · 2021Article
- Vascular Risk Factors and Cognition in Multiple System Atrophy.Frontiers in neuroscience · 2021Article
- Differential diagnosis of parkinsonian syndromes: a comparison of clinical and automated - metabolic brain patterns' based approach.European journal of nuclear medicine and molecular imaging · 2020Article
- Clinical features, MRI, and 18F-FDG-PET in differential diagnosis of Parkinson disease from multiple system atrophy.Brain and behavior · 2020Article
- Article
- Dementia spectrum disorders: lessons learnt from decades with PET research.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson's Disease.Frontiers in immunology · 2019Article
- The clinico-metabolic correlates of language impairment in corticobasal syndrome and progressive supranuclear palsy.NeuroImage. Clinical · 2019Article
- Role of Positron Emission Tomography as a Biologic Marker in the Diagnosis of Primary Progressive Aphasia: Two Case Reports.Nuclear medicine and molecular imaging · 2018Article
- Role of Neuroimaging on Differentiation of Parkinson's Disease and Its Related Diseases.Yonago acta medica · 2018Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo systematically review the previous studies and current status of positron emission tomography (PET) molecular imaging research in atypical parkinsonism.
methodsMEDLINE, ISI Web of Science, Cochrane Library, and Scopus electronic databases were searched for articles published until 29th March 2016 and included brain PET studies in progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and corticobasal syndrome (CBS). Only articles published in English and in peer-reviewed journals were included in this review. Case-reports, reviews, and non-human studies were excluded.
resultsSeventy-seven PET studies investigating the dopaminergic system, glucose metabolism, microglial activation, hyperphosphorilated tau, opioid receptors, the cholinergic system, and GABA
conclusionsPET molecular imaging has provided valuable insight for understanding the mechanisms underlying atypical parkinsonism. Changes at a molecular level occur early in the course of these neurodegenerative diseases and PET imaging provides the means to aid differential diagnosis, monitor disease progression, identify of novel targets for pharmacotherapy, and monitor response to new treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.