ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Operationalizing Frailty in the Atherosclerosis Risk in Communities Study Cohort.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Inflammatory biomarkers in older adults with frailty: a systematic review and meta-analysis of cross-sectional studies.Aging clinical and experimental research · 2022Pooled it
- Effect of Hearing Intervention Versus Health Education Control on Fatigue: A Secondary Analysis of the ACHIEVE Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- Timing of Orthostatic Blood Pressure Changes and Its Association With Orthostatic Symptoms and Falls at Very Old Ages: Findings From the ARIC Study.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Burden and Risk Factors of CGM-Detected Hypoglycemia in Older Adults With Type 2 Diabetes.Journal of the American Geriatrics Society · 2026Article
- Factors Associated With Discordant Blood Pressure Measures among Very Old Adults: Results From the Atherosclerosis Risk in Communities (ARIC) Study.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Alterations in Cardiac Structure and Function Associated With Sub-Severe Aortic Stenosis Progression: The ARIC Study.Journal of the American Heart Association · 2026Article
- The effect of long-term adherence to physical activity recommendations in midlife on plasma proteins associated with frailty in the Atherosclerosis Risk in Communities (ARIC) study.European journal of epidemiology · 2026Article
- Olfaction and Coronary Heart Disease.JAMA otolaryngology-- head & neck surgery · 2026Article
- Prevalence of Peripheral Neuropathy Among Very Old Adults: Evidence From the Michigan Neuropathy Screening Instrument.Journal of the American Geriatrics Society · 2025Article
- Poor olfaction and risk of heart failure in the Atherosclerosis Risk in Communities Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Polypharmacy and Potentially Inappropriate Medications in Adults ≥75 Years of Age by Dementia and Frailty Status: The ARIC Study.Mayo Clinic proceedings · 2025Article
- Association of Body Mass Index in Late Life, and Change from Midlife to Late Life, With Incident Dementia in the ARIC Study Participants.Neurology · 2025Observational
- Frailty and risk of venous thromboembolism in older adults: the Atherosclerosis Risk in Communities Study.Journal of thrombosis and haemostasis : JTH · 2025Article
- Longitudinal Association of Olfactory Function with Frailty in Older Adults: The Atherosclerosis Risk in Communities Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Does Adiponectin Inform Cardiovascular Risk in Older Adults?: The ARIC Study.JACC. Advances · 2025Article
- Poor Olfaction and Risk of Stroke in Older Adults: The Atherosclerosis Risk in Communities Study.Stroke · 2025Article
- Association of left atrial function with frailty: The Atherosclerosis Risk in Communities (ARIC) study.Journal of the American Geriatrics Society · 2024Article
- Mid-life plasma proteins associated with late-life prefrailty and frailty: a proteomic analysis.GeroScience · 2024Article
- Associations of plasma proteomics and age-related outcomes with brain age in a diverse cohort.GeroScience · 2024Article
- Coronary artery calcium as a marker of healthy and unhealthy aging in adults aged 75 and older: The Atherosclerosis Risk in Communities (ARIC) study.Atherosclerosis · 2024Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Background: Factors that may contribute to the development of frailty in late life have not been widely investigated. The Atherosclerosis Risk in Communities (ARIC) Study cohort presents an opportunity to examine relationships of midlife risk factors with frailty in late life. However, we first present findings on the validation of an established frailty phenotype in this predominantly biracial population of older adults. Methods: Among 6,080 participants, we defined frailty based upon the Cardiovascular Health Study (CHS) criteria incorporating measures of weight loss, exhaustion, slow walking speed, low physical activity, and low grip strength. Criterion and predictive validity of the frailty phenotype were estimated from associations between frailty status and participants' physical and mental health status, physiologic markers, and incident clinical outcomes. Results: A total of 393 (6.5%) participants were classified as frail and 50.4% pre-frail, similar to CHS (6.9% frail, 46.6% pre-frail). In age-adjusted analyses, frailty was concurrently associated with depressive symptoms, low self-rated health, low medication adherence, and clinical biomarker levels (ie, cholesterol, hemoglobin A1c, white blood cell count, C-reactive protein, and hemoglobin). During 1-year follow-up, frailty was associated with falls, low physical ability, fatigue, and mortality. Conclusions: These findings support the validity of the CHS frailty phenotype in the ARIC Study cohort. Future studies in ARIC may elucidate early-life exposures that contribute to late-life frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.