ReviewNeurobiology of learning and memory2016
Bridging the Gap: Towards a cell-type specific understanding of neural circuits underlying fear behaviors.
Review in Neurobiology of learning and memory, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Identification of a stress-responsive subregion of the basolateral amygdala in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Acute stress activates basolateral amygdala neurons expressing corticotropin-releasing hormone receptor type 1 (CRHR1): Topographical distribution and projection-specific activation in male and female rats.Neurobiology of stress · 2024Article
- Pre- and postsynaptic N-methyl-D-aspartate receptors are required for sequential printing of fear memory engrams.iScience · 2023Article
- Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior.Cell reports · 2023Article
- Article
- Amygdala Intercalated Cells: Gate Keepers and Conveyors of Internal State to the Circuits of Emotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Genome-wide transcriptomics of the amygdala reveals similar oligodendrocyte-related responses to acute and chronic alcohol drinking in female mice.Translational psychiatry · 2022Article
- Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits.Nature reviews. Neurology · 2022Review
- Amygdala DCX and blood Cdk14 are implicated as cross-species indicators of individual differences in fear, extinction, and resilience to trauma exposure.Molecular psychiatry · 2022Article
- Unlocking the reinforcement-learning circuits of the orbitofrontal cortex.Behavioral neuroscience · 2021Article
- The endocannabinoid system in the amygdala and modulation of fear.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning.Nature communications · 2020Article
- Translating Across Circuits and Genetics Toward Progress in Fear- and Anxiety-Related Disorders.The American journal of psychiatry · 2020Review
- Anterior Cingulate Cortex and Ventral Hippocampal Inputs to the Basolateral Amygdala Selectively Control Generalized Fear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Embracing Complexity in Defensive Networks.Neuron · 2019Review
- Anterior Cingulate Cortex to Ventral Hippocampus Circuit Mediates Contextual Fear Generalization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Preclinical studies of stress, extinction, and prefrontal cortex: intriguing leads and pressing questions.Psychopharmacology · 2019Review
- Contextual fear retrieval-induced Fos expression across early development in the rat: An analysis using established nervous system nomenclature ontology.Neurobiology of learning and memory · 2018Article
- Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction.Translational psychiatry · 2018Article
- An Emerging Circuit Pharmacology of GABATrends in pharmacological sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Fear and anxiety-related disorders are remarkably common and debilitating, and are often characterized by dysregulated fear responses. Rodent models of fear learning and memory have taken great strides towards elucidating the specific neuronal circuitries underlying the learning of fear responses. The present review addresses recent research utilizing optogenetic approaches to parse circuitries underlying fear behaviors. It also highlights the powerful advances made when optogenetic techniques are utilized in a genetically defined, cell-type specific, manner. The application of next-generation genetic and sequencing approaches in a cell-type specific context will be essential for a mechanistic understanding of the neural circuitry underlying fear behavior and for the rational design of targeted, circuit specific, pharmacologic interventions for the treatment and prevention of fear-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.