Evidence map›Paper›PMID 27469596›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2017

Brain Activity and Functional Connectivity Associated with Hypnosis.

Heidi Jiang, Matthew P White, Michael D Greicius, Lynn C Waelde, David Spiegel

2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02969707 nacompletednot on this map

Use of Repetitive Transcranial Magnetic Stimulation to Augment Hypnotic Analgesia

TypeinterventionalSponsorStanford UniversityRan2017 to 2019Enrolled101ConditionsFibromyalgiaArmsMagPro TMS system (MagVenture, Denmark), Hypnosis
NCT05197972 narecruitingnot on this mapstarted 2022, after this paper: background citation

Phase III Study Evaluating a Non-drug Intervention (NDI) Program by Fixed-frequency Guided Breathing (Cardiac Coherence) Associated With Medical Hypnosis on Preoperative Anxiety in Oncological Surgery

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2022 to 2026Enrolled296ConditionsSurgery, OncologyArmscardiac coherence program coupled with hypnosis
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 233 citations in OpenAlex.

  1. Mood-congruent memory revisited.Psychological review · 2023
    Pooled it
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  6. Article
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  9. Review
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  13. Heart Rate Variability, Hypnosis, and Psychotherapy.Applied psychophysiology and biofeedback · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Heidi JiangDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
Matthew P WhiteDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
Michael D GreiciusInterdepartmental Neuroscience Program, Northwestern University, Evanston, IL 60208, USA.
Lynn C WaeldePacific Graduate School of Psychology, Palo Alto University, Palo Alto, CA 94304, USA.
David SpiegelDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
Stanford University · USNorthwestern University · USPalo Alto University · US

Funding

Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
Resting State Functional MRI Investigation of Hypnotic Trance and Mindfulness MedRC1AT005733 · NCCIH · STANFORD UNIVERSITY · PI SPIEGEL, DAVID · 2009 to 2010
$919k
NCCIH NIH HHS RC1 AT005733NIBIB NIH HHS P41 EB015891
6 · The paper itself

Abstract

Hypnosis has proven clinical utility, yet changes in brain activity underlying the hypnotic state have not yet been fully identified. Previous research suggests that hypnosis is associated with decreased default mode network (DMN) activity and that high hypnotizability is associated with greater functional connectivity between the executive control network (ECN) and the salience network (SN). We used functional magnetic resonance imaging to investigate activity and functional connectivity among these three networks in hypnosis. We selected 57 of 545 healthy subjects with very high or low hypnotizability using two hypnotizability scales. All subjects underwent four conditions in the scanner: rest, memory retrieval, and two different hypnosis experiences guided by standard pre-recorded instructions in counterbalanced order. Seeds for the ECN, SN, and DMN were left and right dorsolateral prefrontal cortex, dorsal anterior cingulate cortex (dACC), and posterior cingulate cortex (PCC), respectively. During hypnosis there was reduced activity in the dACC, increased functional connectivity between the dorsolateral prefrontal cortex (DLPFC;ECN) and the insula in the SN, and reduced connectivity between the ECN (DLPFC) and the DMN (PCC). These changes in neural activity underlie the focused attention, enhanced somatic and emotional control, and lack of self-consciousness that characterizes hypnosis.

Indexed as

HypnosisAdultBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMental RecallNeural PathwaysNeuropsychological TestsRestYoung Adultbrain activityfMRIfunctional connectivityhypnosisresting state

Identifiers

PMID27469596
PMCPMC6248753
OpenAlexW2484956421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.